Molecular structure of CH 223191, CAS Number: 301326-22-7
CH 223191 (CAS 301326-22-7)
See product citations (2)
Alternate Names:
1-Methyl-N-[2-methyl-4-[2-(2-methylphenyl)diazenyl]phen yl-1H-pyrazole-5-carboxamide; AhR Antagonist
Application:
CH 223191 is a potent and specific aryl hydrocarbon receptor inhibitor
CAS Number:
301326-22-7
Purity:
≥95%
Molecular Weight:
333.39
Molecular Formula:
C19H19N5O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
CH 223191 is shown to be a potent 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-induced aryl hydrocarbon receptor inhibitor. Mechanistic experiments show that CH 223191 blocks binding of TCDD to AhR and prevents TCDD-mediated nuclear translocation and AhR DNA binding. Detailed studies show that CH 223191 specifically prevents expression of cytochrome P450 enzyme, which is the target gene of AhR. AhR is a transcription factor that mediates cell cycle progression and affects transforming growth factor-beta (TGF-beta) signaling.
CH 223191 (CAS 301326-22-7) References
- Novel compound 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazo-phenyl)-amide (CH-223191) prevents 2,3,7,8-TCDD-induced toxicity by antagonizing the aryl hydrocarbon receptor. | Kim, SH., et al. 2006. Mol Pharmacol. 69: 1871-8. PMID: 16540597
- Natural agonists for aryl hydrocarbon receptor in culture medium are essential for optimal differentiation of Th17 T cells. | Veldhoen, M., et al. 2009. J Exp Med. 206: 43-9. PMID: 19114668
- Aryl hydrocarbon receptor inhibition downregulates the TGF-beta/Smad pathway in human glioblastoma cells. | Gramatzki, D., et al. 2009. Oncogene. 28: 2593-605. PMID: 19465936
- The aryl hydrocarbon receptor agonist 2,3,7,8-tetrachloro-dibenzo-p-dioxin (TCDD) alters early embryonic development in a rat IVF exposure model. | Petroff, BK., et al. 2011. Reprod Toxicol. 32: 286-92. PMID: 21835239
- Cyprodinil as an activator of aryl hydrocarbon receptor. | Fang, CC., et al. 2013. Toxicology. 304: 32-40. PMID: 23228475
- TCDD and omeprazole prime platelets through the aryl hydrocarbon receptor (AhR) non-genomic pathway. | Pombo, M., et al. 2015. Toxicol Lett. 235: 28-36. PMID: 25797602
- Effect of Benzo(a)pyrene on the Expression of miR-483-3p in Hepatocyte Primary Culture and Rat Liver. | Filippov, SV., et al. 2019. Biochemistry (Mosc). 84: 1197-1203. PMID: 31694515
- Aryl hydrocarbon receptor mediates benzo[a]pyrene-induced metabolic reprogramming in human lung epithelial BEAS-2B cells. | Ye, G., et al. 2021. Sci Total Environ. 756: 144130. PMID: 33288249
- β-Naphthoflavone Activation of the Ah Receptor Alleviates Irradiation-Induced Intestinal Injury in Mice. | Zhou, X., et al. 2020. Antioxidants (Basel). 9: PMID: 33322705
- 5-Aminosalicylic Acid, A Weak Agonist for Aryl Hydrocarbon Receptor That Induces Splenic Regulatory T Cells. | Kubota, A., et al. 2022. Pharmacology. 107: 28-34. PMID: 34915497
- Sorafenib is an antagonist of the aryl hydrocarbon receptor. | Wei, KL., et al. 2022. Toxicology. 470: 153118. PMID: 35124147
- Indoleamine 2, 3-Dioxygenase 1 Mediates Survival Signals in Chronic Lymphocytic Leukemia via Kynurenine/Aryl Hydrocarbon Receptor-Mediated MCL1 Modulation. | Atene, CG., et al. 2022. Front Immunol. 13: 832263. PMID: 35371054
- Involvement of polycyclic aromatic hydrocarbons and endotoxin in macrophage expression of interleukin-33 induced by exposure to particulate matter. | Ishihara, N., et al. 2022. J Toxicol Sci. 47: 201-210. PMID: 35527008
- Blocking the Aryl Hydrocarbon Receptor Alleviates Myocardial Ischemia/Reperfusion Injury in Rats. | Wang, JX., et al. 2022. Curr Med Sci. 42: 966-973. PMID: 35788946
Inhibitor of:
Aryl Hydrocarbon Receptor.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CH 223191, 10 mg | sc-293991 | 10 mg | $194.00 | |||
CH 223191, 50 mg | sc-293991A | 50 mg | $831.00 |