| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
JW 55 | 664993-53-7 | sc-364517 sc-364517A | 10 mg 50 mg | $172.00 $726.00 | ||
JW55 is an inhibitor of the enzyme acyl protein thioesterase 1 (APT1), which modulates the palmitoylation status of Wnt signaling components. By inhibiting APT1, JW55 promotes the depalmitoylation and inactivation of Wnt signaling proteins, thereby indirectly reducing Armadillo's activity as it relies on Wnt signal transduction for its activation. | ||||||
LGK 974 | 1243244-14-5 | sc-489380 sc-489380A | 5 mg 50 mg | $352.00 $1270.00 | 2 | |
LGK-974 is a porcupine inhibitor that blocks the palmitoylation and secretion of Wnt proteins. Since Armadillo signaling is activated by Wnt ligands, inhibition of Wnt secretion by LGK-974 leads to reduced activation of Armadillo downstream signaling pathways. | ||||||
PNU-74654 | 113906-27-7 | sc-258020 sc-258020A | 5 mg 25 mg | $128.00 $485.00 | 7 | |
PNU-74654 disrupts the interaction between β-catenin (Armadillo) and T-cell factor (TCF), thus inhibiting the transcriptional activity of Armadillo/TCF complexes. By blocking this interaction, it prevents Armadillo from activating Wnt target genes. | ||||||
PKF118-310 | 84-82-2 | sc-364590 sc-364590A | 5 mg 25 mg | $176.00 $638.00 | ||
PKF118-310 is a small molecule that inhibits the binding of β-catenin (Armadillo) to TCF, leading to repression of Wnt/β-catenin (Armadillo) target genes. The compound thereby decreases the functional activity of Armadillo by preventing it from activating downstream signaling. | ||||||
β-Catenin/Tcf Inhibitor, FH535 | 108409-83-2 | sc-221398 sc-221398A | 10 mg 50 mg | $178.00 $367.00 | 7 | |
FH535 is a dual inhibitor of β-catenin (Armadillo) and peroxisome proliferator-activated receptor (PPAR). It inhibits the Wnt/β-catenin (Armadillo) signaling pathway by preventing the formation of the Armadillo/TCF transcriptional complex, thus reducing Armadillo-mediated transcription. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin is a flavonoid that has been shown to inhibit the Wnt/β-catenin (Armadillo) signaling pathway. It acts by promoting the degradation of Armadillo and by inhibiting its interaction with TCF, leading to downregulation of Armadillo target gene expression. | ||||||