Date published: 2025-12-24

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Armadillo Inhibitors

Armadillo inhibitors are a distinctive chemical class that has gained considerable attention in scientific research and discovery. These inhibitors are designed to target and modulate a specific cellular protein known as Armadillo, which plays a crucial role in various biological processes. Armadillo is a key component of cellular signaling pathways involved in cell growth, development, and communication. By selectively binding to Armadillo, these inhibitors disrupt its normal function and interfere with the intricate cellular mechanisms that rely on its participation. The unique chemical structure of armadillo inhibitors enables them to interact with specific regions of the Armadillo protein, hampering its ability to form functional complexes with other proteins or DNA. The development and characterization of armadillo inhibitors have involved rigorous chemical synthesis and structural optimization, allowing researchers to fine-tune their selectivity and affinity towards Armadillo. This precise manipulation of their chemical properties enhances their efficacy and minimizes off-target effects. Researchers have also utilized cutting-edge techniques such as X-ray crystallography and computational modeling to unravel the structural details of the inhibitor-Armadillo interaction, further deepening our understanding of the molecular interactions at play. In conclusion, armadillo inhibitors represent a unique class of compounds that hold great promise in elucidating the intricate roles of Armadillo in cellular processes. Their targeted modulation of Armadillo function provides invaluable insights into the fundamental workings of signaling pathways, contributing to our overall understanding of cellular biology. While their potential applications remain a subject of ongoing investigation, the scientific community eagerly awaits further advancements in this exciting field of research.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

JW 55

664993-53-7sc-364517
sc-364517A
10 mg
50 mg
$172.00
$726.00
(0)

JW55 is an inhibitor of the enzyme acyl protein thioesterase 1 (APT1), which modulates the palmitoylation status of Wnt signaling components. By inhibiting APT1, JW55 promotes the depalmitoylation and inactivation of Wnt signaling proteins, thereby indirectly reducing Armadillo's activity as it relies on Wnt signal transduction for its activation.

LGK 974

1243244-14-5sc-489380
sc-489380A
5 mg
50 mg
$352.00
$1270.00
2
(0)

LGK-974 is a porcupine inhibitor that blocks the palmitoylation and secretion of Wnt proteins. Since Armadillo signaling is activated by Wnt ligands, inhibition of Wnt secretion by LGK-974 leads to reduced activation of Armadillo downstream signaling pathways.

PNU-74654

113906-27-7sc-258020
sc-258020A
5 mg
25 mg
$128.00
$485.00
7
(2)

PNU-74654 disrupts the interaction between β-catenin (Armadillo) and T-cell factor (TCF), thus inhibiting the transcriptional activity of Armadillo/TCF complexes. By blocking this interaction, it prevents Armadillo from activating Wnt target genes.

PKF118-310

84-82-2sc-364590
sc-364590A
5 mg
25 mg
$176.00
$638.00
(1)

PKF118-310 is a small molecule that inhibits the binding of β-catenin (Armadillo) to TCF, leading to repression of Wnt/β-catenin (Armadillo) target genes. The compound thereby decreases the functional activity of Armadillo by preventing it from activating downstream signaling.

β-Catenin/Tcf Inhibitor, FH535

108409-83-2sc-221398
sc-221398A
10 mg
50 mg
$178.00
$367.00
7
(1)

FH535 is a dual inhibitor of β-catenin (Armadillo) and peroxisome proliferator-activated receptor (PPAR). It inhibits the Wnt/β-catenin (Armadillo) signaling pathway by preventing the formation of the Armadillo/TCF transcriptional complex, thus reducing Armadillo-mediated transcription.

Quercetin

117-39-5sc-206089
sc-206089A
sc-206089E
sc-206089C
sc-206089D
sc-206089B
100 mg
500 mg
100 g
250 g
1 kg
25 g
$11.00
$17.00
$108.00
$245.00
$918.00
$49.00
33
(2)

Quercetin is a flavonoid that has been shown to inhibit the Wnt/β-catenin (Armadillo) signaling pathway. It acts by promoting the degradation of Armadillo and by inhibiting its interaction with TCF, leading to downregulation of Armadillo target gene expression.