ARL4D Activators
ARL4D Activators are a group of chemical compounds selected for their ability to potentially enhance the functional activity of ARL4D, a GTP-binding protein that plays a significant role in cellular processes like vesicle trafficking and actin cytoskeleton remodeling. GTPγS, by stabilizing ARL4D in its active state, directly enhances its GTPase activity, which is central to its function.
The inclusion of cytoskeletal modulators such as Cytochalasin D, Jasplakinolide, and Latrunculin B is based on ARL4D's involvement in actin cytoskeleton organization. By altering actin dynamics, these compounds could enhance ARL4D's regulatory activity in cytoskeletal remodeling, essential for processes like cell migration. Additionally, ROCK inhibitor Y-27632 indirectly modulates ARL4D's function by affecting related signaling cascades. Post-translational modification inhibitors like Farnesyltransferase Inhibitor (FTI-277) and Geranylgeranyltransferase Inhibitor (GGTI-298) are included for their potential impact on ARL4D's localization and membrane-associated functions. Wiskostatin, as an inhibitor of N-WASP, further highlights the intricate relationship between ARL4D and actin cytoskeleton dynamics.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Guanosine 5′-O-(3-thiotriphosphate) tetralithium salt | 94825-44-2 | sc-202639 | 10 mg | $465.00 | ||
A non-hydrolyzable GTP analog, stabilizes ARL4D in its active GTP-bound form, potentially enhancing its GTPase activity. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
Disrupts actin polymerization, potentially influencing ARL4D's role in actin cytoskeleton remodeling. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $184.00 $305.00 | 59 | |
Stabilizes actin filaments, potentially enhancing ARL4D's role in actin cytoskeleton organization. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
A ROCK inhibitor, could indirectly affect ARL4D's activity by altering Rho kinase-mediated signaling pathways. | ||||||
GGTI 298 | 1217457-86-7 | sc-361184 sc-361184A | 1 mg 5 mg | $193.00 $838.00 | 2 | |
Prevents geranylgeranylation, possibly influencing ARL4D's role in membrane trafficking. | ||||||
Wiskostatin | 253449-04-6 | sc-204399 sc-204399A sc-204399B sc-204399C | 1 mg 5 mg 25 mg 50 mg | $49.00 $124.00 $441.00 $828.00 | 4 | |
Inhibits N-WASP, potentially affecting ARL4D's involvement in actin dynamics. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $265.00 $815.00 | 36 | |
Disrupts actin filaments, could amplify ARL4D's role in cytoskeletal reorganization. | ||||||