ARL4D Inhibitors
Chemical inhibitors of ARL4D can impede its function through various mechanisms that target the protein's GTPase activity or the signaling pathways in which it is involved. Brefeldin A disrupts the ARF family proteins, to which ARL4D belongs, by preventing the exchange of GDP for GTP, crucial for ARL4D's activation and function. Similarly, SecinH3 targets cytohesins, which are the guanine nucleotide exchange factors for ARF proteins, thus impeding ARL4D's activation. ML141, although a Cdc42 GTPase inhibitor, could indirectly interfere with GTPase activity that ARL4D might rely on, while CID1067700, as a selective inhibitor of Rho GTPase, could obstruct pathways that indirectly govern ARL4D's role in actin cytoskeleton organization. ZCL278 and EHT 1864, both Cdc42 and Rac GTPase inhibitors, respectively, can halt interactions between these GTPases and their effectors, potentially affecting ARL4D's function within these pathways.
NSC23766, by impeding Rac1 GTPase activation, and Rhosin, through inhibition of RhoA GTPase activation, could both lead to the downstream functional inhibition of ARL4D if it is involved in or regulated by RhoA or Rac1 signaling pathways. IPA-3, which selectively obstructs PAKs, the downstream effectors of GTPases, can indirectly inhibit ARL4D if it relies on PAK-dependent pathways for its activation. Exoenzyme C3 from Clostridium botulinum inactivates Rho GTPases, potentially leading to the inhibition of ARL4D if it is influenced by Rho-mediated signaling. Lastly, CASIN blocks Cdc42 activity, which can have an overarching effect on the GTPase family, including the possible inhibition of the function of ARL4D by reducing the activity of Cdc42, which may be critical for ARL4D's regulatory mechanisms.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Brefeldin A disrupts the ARF family of GTP-binding proteins by inhibiting the exchange of GDP for GTP. As ARL4D is a member of the ARF family, Brefeldin A would inhibit ARL4D by preventing its activation through GDP-GTP exchange, essential for its function. | ||||||
SecinH3 | 853625-60-2 | sc-203260 | 5 mg | $273.00 | 6 | |
SecinH3 specifically inhibits cytohesin family members, which are guanine nucleotide exchange factors (GEFs) for ARF proteins. By inhibiting these GEFs, SecinH3 would prevent the activation of ARL4D, as it requires GEFs for its GDP-GTP exchange activity. | ||||||
ML 141 | 71203-35-5 | sc-362768 sc-362768A | 5 mg 25 mg | $134.00 $502.00 | 7 | |
ML141 is a Cdc42 GTPase inhibitor. Given that GTPase activity is crucial for the function of ARL4D, ML141 can indirectly inhibit ARL4D by modulating the GTPase activity upon which ARL4D may indirectly depend for its regulatory functions. | ||||||
2-(Benzoylcarbamothioylamino)-5,5-dimethyl-4,7-dihydrothieno[2,3-c]pyran-3-carboxylic Acid | 314042-01-8 | sc-503400 | 10 mg | $300.00 | ||
CID1067700 selectively inhibits Rho GTPase activity. As ARL4D function could be related to the Rho GTPase signaling pathway, the inhibition of Rho GTPases can indirectly inhibit ARL4D's function in actin cytoskeleton organization. | ||||||
ZCL278 | 587841-73-4 | sc-507369 | 10 mg | $115.00 | ||
ZCL278 is a Cdc42 GTPase inhibitor that hinders the interaction between Cdc42 and its effectors. By disrupting this interaction, ZCL278 can indirectly inhibit ARL4D if it relies on Cdc42 for part of its signaling pathway or cytoskeletal organization. | ||||||
NSC 23766 | 733767-34-5 | sc-204823 sc-204823A | 10 mg 50 mg | $148.00 $597.00 | 75 | |
NSC23766 specifically inhibits Rac1 GTPase by blocking its interaction with GEFs. If ARL4D's function is connected to Rac1 signaling pathways, this inhibitor would indirectly impair ARL4D by inhibiting Rac1 activation. | ||||||
EHT 1864 | 754240-09-0 | sc-361175 sc-361175A | 10 mg 50 mg | $209.00 $872.00 | 12 | |
EHT 1864 is a Rac family small GTPase inhibitor; it stabilizes Rac in an inactive state. ARL4D, potentially interacting within Rac-regulated pathways, would be functionally inhibited by the downregulation of Rac activity. | ||||||
IPA 3 | 42521-82-4 | sc-204016 sc-204016A | 5 mg 50 mg | $92.00 $449.00 | 6 | |
IPA-3 selectively inhibits the PAKs (p21-activated kinases), downstream effectors of small GTPases like Cdc42 and Rac. Inhibition of PAKs can indirectly inhibit ARL4D if its function is mediated by PAK-dependent pathways. | ||||||
CASIN | 425399-05-9 | sc-397016 | 10 mg | $460.00 | 1 | |
CASIN inhibits Cdc42, which in turn can affect the GTPase family at large, including ARL4D. By targeting Cdc42's activity, CASIN may indirectly inhibit the activation and function of ARL4D. | ||||||
Rhosin | 1173671-63-0 | sc-507401 | 25 mg | $555.00 | ||
Rhosin specifically inhibits RhoA interaction with GEFs, impeding the activation of RhoA. If ARL4D operates within or interacts with RhoA-mediated signaling pathways, Rhosin can lead to the indirect functional inhibition of ARL4D. | ||||||