ARL10 Inhibitors
ARL10 inhibitors encompass a diverse group of chemical compounds that exert their inhibitory effects through various signaling pathways and molecular mechanisms, ultimately leading to the diminution of ARL10's functional activity. Kinase inhibitors, for instance, play a critical role in the modulation of ARL10 activity by targeting phosphorylation events which are essential for the protein's role in signal transduction and cellular communication. The inhibition of key kinases involved in the RAF/MEK/ERK and PI3K/AKT pathways by specific small molecules may lead to a downstream suppression of ARL10 activity, given its potential interactions with these pathways. Similarly, compounds that target the cytoskeletal organization, such as those inhibiting the ROCK pathway, may also indirectly diminish ARL10's role in cellular architecture by stabilizing actin structures and thus impacting ARL10-mediated remodeling.
Furthermore, inhibitors that modulate stress response pathways and other kinase-mediated signaling processes such as the JNK and p38 MAP kinase pathways could indirectly reduce ARL10's activity by preventing its participation in cellular stress responses. In addition, G-protein antagonists that disrupt G-protein-mediated signaling caninfluence ARL10 due to its classification within the ARF family of GTP-binding proteins. The comprehensive inhibition of ARL10 is achieved not only through the direct blockage of pathways it is known or predicted to be part of but also by stabilizing molecular structures or inhibiting regulatory kinases that would otherwise facilitate ARL10's involvement in crucial cellular processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
A potent kinase inhibitor that disrupts multiple signaling pathways, including those regulated by ARL10. Staurosporine inhibits phosphorylation events that could be essential for ARL10's role in signal transduction, leading to its functional inhibition. | ||||||
GW 5074 | 220904-83-6 | sc-200639 sc-200639A | 5 mg 25 mg | $106.00 $417.00 | 10 | |
A c-RAF kinase inhibitor that impacts the RAF/MEK/ERK signaling cascade. As ARL10 is a GTP-binding protein that could interact with kinases in signal transduction, GW5074's inhibition of RAF kinase may lead to the downstream inhibition of ARL10 activity. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
A ROCK inhibitor that can decrease the phosphorylation status of various downstream targets, affecting the actin cytoskeleton. Since ARL10 is implicated in cytoskeletal organization, Y-27632 may indirectly inhibit ARL10 by stabilizing actin structures and preventing ARL10-mediated remodeling. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A PI3K inhibitor that blocks the PI3K/AKT pathway. ARL10 might interact with components of this pathway or be modulated by PI3K activity; thus, LY294002's inhibition of PI3K can result in decreased ARL10 function. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
A MEK inhibitor that prevents the activation of ERK1/2. ARL10 could be involved in ERK-mediated signaling processes, so PD98059 could indirectly inhibit ARL10 through the suppression of ERK activity. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
A p38 MAP kinase inhibitor that may alter stress response pathways. Given ARL10 functions in response to cellular stress, SB203580 could inhibit ARL10 by preventing activation of the p38 pathway. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
An inhibitor of PI3K that could disrupt signaling pathways involving ARL10. By blocking PI3K, wortmannin may indirectly inhibit ARL10's function in these pathways. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
A JNK inhibitor that modifies the JNK signaling pathway. Given that ARL10 may have a role in cellular stress mechanisms that involve JNK signaling, inhibition by SP600125 could translate to reduced ARL10 activity. | ||||||
ZM 336372 | 208260-29-1 | sc-202857 | 1 mg | $46.00 | 2 | |
A c-RAF kinase inhibitor that could suppress the RAF/MEK/ERK pathway. This inhibition may indirectly decrease ARL10's functional activity. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
A PKC inhibitor that can prevent PKC-mediated signaling. As ARL10 might be involved in pathways that are regulated by PKC activity, Bisindolylmaleimide I's inhibition of PKC could lead to reduced ARL10 function. | ||||||