Apoptotic Myeloid Marker Activators
Apoptotic Myeloid Marker activators encompass a diverse array of chemical compounds that influence apoptosis in myeloid cells, thereby potentially amplifying the functional activity of the Apoptotic Myeloid Marker. Compounds such as Z-VAD-FMK and BH3 Mimetic (ABT-737) impact the intrinsic pathways of apoptosis; while Z-VAD-FMK acts as a pan-caspase inhibitor which can inadvertently increase apoptosis under certain conditions, ABT-737 directly antagonizes Bcl-2 proteins to promote apoptotic cell death. Similarly, Venetoclax, another Bcl-2 inhibitor, elevates apoptotic processes, thereby potentially enhancing Apoptotic Myeloid Marker activity. Etoposide and Bortezomib, by inducing DNA damage and proteasome inhibition respectively, can escalate the apoptotic cascade, leading to an upsurge in the marker's activity. Sunitinib, although primarily a tyrosine kinase inhibitor, has off-target effects that may include the promotion of apoptosis, indirectly influencing the Apoptotic Myeloid Marker.
Furthermore, the balance between survival and death signaling is delicately modulated by compounds like Staurosporine and JNK Inhibitor IX, which through broad-spectrum kinase inhibition and specific JNK inhibition, respectively, can tilt the balance towards apoptosis. Necrostatin-1 and Cycloheximide also contribute by inhibiting alternative cell death pathways or proteinApoptotic Myeloid Marker activators encompass a diverse array of chemical compounds that influence apoptosis in myeloid cells, thereby potentially amplifying the functional activity of the Apoptotic Myeloid Marker. Compounds such as Z-VAD-FMK and BH3 Mimetic (ABT-737) impact the intrinsic pathways of apoptosis; while Z-VAD-FMK acts as a pan-caspase inhibitor which can inadvertently increase apoptosis under certain conditions, ABT-737 directly antagonizes Bcl-2 proteins to promote apoptotic cell death. Similarly, Venetoclax, another Bcl-2 inhibitor, elevates apoptotic processes, thereby potentially enhancing Apoptotic Myeloid Marker activity.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Z-VAD-FMK | 187389-52-2 | sc-3067 | 500 µg | $74.00 | 256 | |
A pan-caspase inhibitor that, paradoxically, can sometimes enhance apoptosis in myeloid cells, potentially increasing the activity of Apoptotic Myeloid Marker by preventing early caspase-mediated degradation. | ||||||
Necrostatin-1 | 4311-88-0 | sc-200142 sc-200142A | 20 mg 100 mg | $92.00 $336.00 | 97 | |
An inhibitor of RIPK1, which is part of the necroptosis signaling pathway. Its inhibition can shift cell death towards apoptosis, therefore possibly enhancing the Apoptotic Myeloid Marker activity. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
An inhibitor of protein synthesis that can sensitize cells to apoptosis, indirectly enhancing the activity of the Apoptotic Myeloid Marker by promoting apoptotic processes in myeloid cells. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
A broad-spectrum protein kinase inhibitor that promotes apoptosis through a variety of pathways, potentially increasing the activity of Apoptotic Myeloid Marker. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
A topoisomerase II inhibitor that induces DNA damage and apoptosis, potentially enhancing the activities of markers like the Apoptotic Myeloid Marker as a consequence of increased apoptotic events. | ||||||
ABT 737 | 852808-04-9 | sc-207242 | 2.5 mg | $200.00 | 54 | |
A Bcl-2 family protein inhibitor that promotes apoptosis, thereby potentially increasing the activity of the Apoptotic Myeloid Marker through the intrinsic apoptotic pathway. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
A proteasome inhibitor that can induce apoptosis in myeloid cells, indirectly enhancing the activity of the Apoptotic Myeloid Marker. | ||||||
Sunitinib, Free Base | 557795-19-4 | sc-396319 sc-396319A | 500 mg 5 g | $150.00 $920.00 | 5 | |
A tyrosine kinase inhibitor that can induce apoptosis in certain cells, potentially increasing the activity of Apoptotic Myeloid Markers through off-target effects. | ||||||
ABT-199 | 1257044-40-8 | sc-472284 sc-472284A sc-472284B sc-472284C sc-472284D | 1 mg 5 mg 10 mg 100 mg 3 g | $116.00 $330.00 $510.00 $816.00 $1632.00 | 10 | |
A selective Bcl-2 inhibitor that promotes apoptosis, potentially enhancing the activity of Apoptotic Myeloid Marker by shifting the apoptotic balance. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
An inducer of endoplasmic reticulum stress that leads to apoptosis, possibly enhancing the activity of Apoptotic Myeloid Marker through the ER stress-induced apoptotic pathway. | ||||||