APC10 Activators
The chemical class known as APC10 Activators would consist of compounds that modulate cellular pathways to indirectly influence the activity of APC10, a core component of the APC/C complex. These chemicals operate through various mechanisms such as proteasome inhibition, kinase activity modulation, alteration of gene expression, or changes in protein stability and localization.
APC10 activators like MG132 and Bortezomib, through their proteasome inhibition, could lead to the accumulation of APC/C substrates, potentially triggering a feedback response that enhances APC/C activity. Compounds such as ProTAME and MLN4924 interact with the ubiquitin-proteasome system in a manner that could indirectly activate APC/C by perturbing protein turnover and cellular homeostasis. Histone deacetylase inhibitors like Sodium Butyrate and TrSince APC10 is a component of the anaphase-promoting complex (APC/C), a ubiquitin ligase that controls progression through specific stages of the cell cycle, its direct chemical activators are not well-documented. Therefore, we must consider chemicals that can potentially influence the activity of APC/C through indirect mechanisms.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Caspase-3 Inhibitor | 210344-95-9 | sc-3075 | 0.5 mg | $110.00 | 57 | |
ProTAME is an inhibitor of the APC/C that, at suboptimal concentrations, may paradoxically cause an upregulation of APC/C activity as a cellular compensatory mechanism. | ||||||
MLN 4924 | 905579-51-3 | sc-484814 | 1 mg | $280.00 | 1 | |
MLN4924 inhibits NEDD8 activating enzyme, which is necessary for the neddylation process that regulates the activity of Cullin-RING E3 ubiquitin ligases (CRLs). This inhibition could lead to compensatory mechanisms that indirectly enhance APC/C activity. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $92.00 $260.00 | 42 | |
Roscovitine is a cyclin-dependent kinase inhibitor, and by inhibiting certain CDKs, it may indirectly augment APC/C activity due to the intricate balance between CDKs and APC/C during the cell cycle. | ||||||
Leptomycin B | 87081-35-4 | sc-358688 sc-358688A sc-358688B | 50 µg 500 µg 2.5 mg | $105.00 $408.00 $1224.00 | 35 | |
Leptomycin B is an inhibitor of nuclear export. By preventing the export of APC/C regulators, it may indirectly increase their nuclear concentration, thereby enhancing APC/C activity. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate is a histone deacetylase inhibitor that can lead to changes in chromatin structure and gene expression, potentially increasing the expression of APC/C components or associated regulators. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
TSA is another histone deacetylase inhibitor that could affect gene expression and possibly lead to an upregulation of APC/C components or its regulatory proteins. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Chloride inhibits GSK-3, a kinase that may regulate APC/C activity. Inhibition of GSK-3 could cause changes in the phosphorylation state of APC/C or its substrates, potentially influencing its activity. | ||||||
MLN8237 | 1028486-01-2 | sc-394162 | 5 mg | $220.00 | ||
MLN8237 is an Aurora A kinase inhibitor. Since Aurora A kinase interacts with the APC/C, its inhibition may alter the phosphorylation status of APC/C components, affecting their activity. | ||||||
Palbociclib | 571190-30-2 | sc-507366 | 50 mg | $315.00 | ||
PD0332991 is a CDK4/6 inhibitor, and by affecting the CDK activity, it could indirectly impact the function of APC/C due to the close regulatory relationship between CDKs and APC/C. | ||||||