AOX1 Inhibitors
AOX1 inhibitors belong to a class of chemical compounds designed to selectively target and modulate the activity of the enzyme aldehyde oxidase 1 (AOX1). AOX1 is a molybdo-flavoenzyme found in various tissues, including the liver, and plays a crucial role in the metabolism of a diverse range of endogenous and exogenous compounds. The enzyme catalyzes the oxidation of aldehydes to carboxylic acids, contributing to the biotransformation of xenobiotics and the elimination of potentially toxic substances from the body. AOX1 inhibitors, therefore, exert their effects by interfering with the normal enzymatic activity of AOX1, leading to altered metabolic pathways and the modulation of downstream physiological processes.
The development of AOX1 inhibitors is of particular interest in the field of chemical biology and pharmacology, as these compounds offer a valuable tool to study the specific roles of AOX1 in various biological processes. By selectively inhibiting AOX1, researchers can investigate the impact of altered aldehyde metabolism on the fate and effects of different drugs, environmental toxins, and endogenous substrates.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Raloxifene | 84449-90-1 | sc-476458 | 1 g | $802.00 | 3 | |
Raloxifene can inhibit AOX1 by binding to the enzyme's active site, thus preventing substrate access. | ||||||
Vitamin K3 | 58-27-5 | sc-205990B sc-205990 sc-205990A sc-205990C sc-205990D | 5 g 10 g 25 g 100 g 500 g | $26.00 $36.00 $47.00 $136.00 $455.00 | 3 | |
Menadione interacts with the flavin group in AOX1, altering its redox state and enzyme activity. | ||||||
1-Hydrazinophthalazine Hydrochloride | 304-20-1 | sc-206167 | 10 g | $280.00 | ||
Hydralazine can bind to AOX1 and interfere with electron transfer, inhibiting enzymatic activity. | ||||||
Methimazole | 60-56-0 | sc-205747 sc-205747A | 10 g 25 g | $70.00 $112.00 | 4 | |
Methimazole acts as an inhibitor by irreversibly modifying the AOX1 catalytic site. | ||||||
Chlorpropamide | 94-20-2 | sc-234350 | 25 g | $73.00 | 7 | |
Chlorpropamide binds to AOX1 and inhibits its ability to oxidize other substrates. | ||||||
Pyrimethamine | 58-14-0 | sc-208190 sc-208190A sc-208190B | 1 g 5 g 25 g | $80.00 $238.00 $825.00 | 5 | |
Pyrimethamine can inhibit AOX1 by binding to the molybdenum cofactor, which is essential for activity. | ||||||
Indomethacin | 53-86-1 | sc-200503 sc-200503A | 1 g 5 g | $29.00 $38.00 | 18 | |
Indomethacin binds non-competitively to AOX1, reducing its catalytic efficiency. | ||||||
Naproxen | 22204-53-1 | sc-200506 sc-200506A | 1 g 5 g | $24.00 $41.00 | ||
Naproxen inhibits AOX1 by acting as a non-substrate inhibitor, blocking the access of actual substrates. | ||||||
Phenothiazine | 92-84-2 | sc-250686 sc-250686A | 50 g 250 g | $23.00 $44.00 | ||
Phenothiazine can inhibit AOX1 by altering the enzyme's tertiary or quaternary structure. | ||||||
Mefenamic acid | 61-68-7 | sc-205380 sc-205380A | 25 g 100 g | $106.00 $208.00 | 6 | |
Mefenamic acid binds to AOX1 and inhibits its enzymatic activity by steric hindrance. | ||||||