AOX1 Antibody (D-8): sc-365291

AOX1 Antibody (D-8) is a mouse monoclonal IgG1 kappa light chain antibody that detects AOX1 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). AOX1 Antibody (D-8) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. AOX1, or Aldehyde oxidase 1, is a crucial cytoplasmic enzyme composed of 1,338 amino acids that plays a significant role in the metabolism of aldehydes, catalyzing their oxidation and leading to the production of hydrogen peroxide. This enzymatic activity helps regulate oxidative stress within cells; however, under certain conditions, AOX1 can also generate superoxide free radicals, which are harmful and can contribute to cellular damage. AOX1 is involved in neurodegenerative diseases, particularly amyotrophic lateral sclerosis (ALS), where defects in oxygen radical metabolism have been implicated in disease pathogenesis. AOX1 is highly expressed in the ventral horn of the spinal cord, and the gene encoding AOX1 is located in a chromosomal region frequently associated with ALS2, suggesting a potential role as a candidate gene for this condition. Anti-AOX1 antibody (D-8) effectively detects this protein across various applications, making AOX1 (D-8) monoclonal antibody an essential tool for researchers studying oxidative stress and neurodegenerative diseases.

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AOX1 Antibody (D-8) References:

1. The aldehyde oxidase gene cluster in mice and rats. Aldehyde oxidase homologue 3, a novel member of the molybdo-flavoenzyme family with selective expression in the olfactory mucosa.  |  Kurosaki, M., et al. 2004. J Biol Chem. 279: 50482-98. PMID: 15383531
2. Avian and canine aldehyde oxidases. Novel insights into the biology and evolution of molybdo-flavoenzymes.  |  Terao, M., et al. 2006. J Biol Chem. 281: 19748-61. PMID: 16672219
3. Mammalian aldehyde oxidases: genetics, evolution and biochemistry.  |  Garattini, E., et al. 2008. Cell Mol Life Sci. 65: 1019-48. PMID: 18066686
4. Properties of 130 kDa subunit of monkey aldehyde oxidase.  |  Asakawa, T., et al. 2008. Biol Pharm Bull. 31: 380-5. PMID: 18310896
5. Functional analysis of aldehyde oxidase using expressed chimeric enzyme between monkey and rat.  |  Itoh, K., et al. 2009. Biol Pharm Bull. 32: 31-5. PMID: 19122276
6. Effects of selenium deficiency on aldehyde oxidase 1 in rats.  |  Itoh, K., et al. 2009. Biol Pharm Bull. 32: 190-4. PMID: 19182374
7. Analysis of aldehyde oxidase and xanthine dehydrogenase/oxidase as possible candidate genes for autosomal recessive familial amyotrophic lateral sclerosis.  |  Berger, R., et al. 1995. Somat Cell Mol Genet. 21: 121-31. PMID: 7570184
8. cDNA cloning, characterization, and tissue-specific expression of human xanthine dehydrogenase/xanthine oxidase.  |  Wright, RM., et al. 1993. Proc Natl Acad Sci U S A. 90: 10690-4. PMID: 8248161

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-AOX1 Antibody (D-8) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-AOX1 Antibody (D-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

AOX1 Antibody (D-8) Specifications

Alternate Product Name: AOX1

Product Clone Name: D-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 854-917

Epitope Target: AOX1

Epitope Species: human

Product Reactivity/Detection: AOX1

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for AOX1 Antibody (D-8): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin