AOF1 Activators
AOF1 (Lysine Demethylase 1B) Activators represent a class of chemical compounds designed to modulate the activity of the Lysine Demethylase 1B (AOF1) enzyme, a critical player in the epigenetic regulation of gene expression. AOF1 is a member of the Jumonji C (JmjC) domain-containing histone demethylase family, and its primary function is the removal of methyl groups from lysine residues on histone proteins. This demethylation process, which occurs on histone H3 lysine 4 (H3K4), is pivotal in controlling chromatin structure and, by extension, gene expression. AOF1, specifically, is known for its preference for mono- and di-methylated lysine 4 residues on histone H3.
AOF1 activators are characterized by their ability to enhance the catalytic activity of the AOF1 enzyme. By binding to AOF1 and modifying its conformation or catalytic site, these compounds can increase its efficiency in demethylating histone H3K4, thereby altering the epigenetic landscape of a cell. This, in turn, can influence gene expression patterns and have far-reaching implications for cellular processes such as differentiation, proliferation, and response to environmental cues.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $57.00 $191.00 $302.00 $450.00 $1800.00 $3570.00 $10710.00 | 4 | |
Indirectly activates AOF1/KDM1B by modulating epigenetic and metabolic processes. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Indirectly stimulates AOF1/KDM1B by altering histone acetylation patterns, leading to changes in the epigenetic landscape and gene expression. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Indirectly enhances AOF1/KDM1B by modulating histone acetylation, promoting the balance of epigenetic modifications. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
Indirectly triggers AOF1/KDM1B by influencing DNA methylation patterns, activating chromatin structure and gene regulation. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Indirectly encourages AOF1/KDM1B through its potential effects on gene expression and epigenetic regulation, by activating PKC and MAPK pathways. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Indirectly prompts AOF1/KDM1B by modulating the mTOR pathway, stimulating the cellular environment. | ||||||
Cyclopamine | 4449-51-8 | sc-200929 sc-200929A | 1 mg 5 mg | $94.00 $208.00 | 19 | |
Indirectly impacts AOF1/KDM1B by modulating the expression of genes associated with cellular processes and differentiation through inhibition of the Hedgehog signaling pathway. | ||||||
2-Amino-6-chloro-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic Acid Ethyl Ester | 305834-79-1 | sc-479756 | 25 mg | $380.00 | ||
Indirectly triggers AOF1/KDM1B by potentially modulating the PI3K/AKT signaling pathway, promoting gene expression and cellular processes. | ||||||