ANKRD36B Activators
Chemical activators of ANKRD36B can play a significant role in its functional state through different biochemical mechanisms. Zinc Chloride provides zinc ions that directly interact with ANKRD36B, possibly resulting in a conformational change that stabilizes its active form. Similarly, Magnesium Chloride supplies magnesium ions essential for the function of various kinases. These kinases, upon activation, can phosphorylate ANKRD36B, leading to its activation. Another activator, Sodium Orthovanadate, acts as a phosphatase inhibitor, preventing the dephosphorylation and consequent deactivation of ANKRD36B, thereby maintaining its phosphorylated, active state. Forskolin, by elevating cAMP levels within the cell, activates protein kinase A (PKA), which is known to phosphorylate various target proteins, including ANKRD36B, thus promoting its activation.
Continuing the overview of chemical activators, Okadaic Acid and Calyculin A function as inhibitors of the protein phosphatases that dephosphorylate ANKRD36B, thereby keeping ANKRD36B in an activated phosphorylated state. Phorbol 12-myristate 13-acetate (PMA) is known to activate protein kinase C (PKC), which can then phosphorylate and activate ANKRD36B. The cAMP analog 8-Bromo-cAMP serves a similar function to Forskolin by activating PKA, which can target ANKRD36B for activation through phosphorylation. Ionomycin, by increasing intracellular calcium levels, affects calcium-dependent kinases that may phosphorylate and activate ANKRD36B. Epidermal Growth Factor (EGF) activates its receptor, initiating a cascade of kinase activity that can result in the phosphorylation and activation of ANKRD36B. Hydrogen Peroxide acts as a signaling molecule that can modulate kinase activity, potentially leading to the activation of ANKRD36B. Lastly, Calcium Chloride provides calcium ions that can activate calcium-dependent kinases, which in turn may phosphorylate and activate ANKRD36B, demonstrating the diverse mechanisms through which chemical activators can influence the active state of ANKRD36B.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc ions from Zinc Chloride can directly bind to ANKRD36B, which may stabilize its structure and enhance its catalytic activity. | ||||||
Magnesium chloride | 7786-30-3 | sc-255260C sc-255260B sc-255260 sc-255260A | 10 g 25 g 100 g 500 g | $27.00 $34.00 $47.00 $123.00 | 2 | |
Magnesium ions are critical for many kinase activities; Magnesium Chloride can provide these ions to activate kinases that phosphorylate ANKRD36B, leading to its activation. | ||||||
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $45.00 $56.00 $183.00 | 142 | |
As a phosphatase inhibitor, Sodium Orthovanadate can prevent dephosphorylation of ANKRD36B, maintaining it in an activated state. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin raises cAMP levels which can activate PKA; PKA may phosphorylate ANKRD36B, resulting in its functional activation. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic Acid inhibits protein phosphatases that dephosphorylate ANKRD36B, thus keeping it in an activated state. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $160.00 $750.00 | 59 | |
Similar to Okadaic Acid, Calyculin A inhibits phosphatases that could dephosphorylate ANKRD36B, thereby maintaining its activation. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates PKC which could phosphorylate and activate ANKRD36B. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $97.00 $224.00 | 30 | |
This cAMP analog activates PKA which may target ANKRD36B for phosphorylation and activation. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
By raising intracellular calcium levels, Ionomycin affects calcium-dependent kinases which could phosphorylate and activate ANKRD36B. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $30.00 $60.00 $93.00 | 27 | |
As a signaling molecule, Hydrogen Peroxide can modify kinase activity, potentially leading to the activation of kinases that phosphorylate ANKRD36B. | ||||||