Date published: 2025-9-29

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Androgen Receptor Activators

Androgen receptor activators, or AR activators, belong to a group of compounds that have the ability to engage and activate the androgen receptor (AR), a type of nuclear receptor found in various cells throughout the body. The AR plays a crucial role in mediating the effects of androgens, which are a group of steroid hormones that include testosterone and dihydrotestosterone (DHT). In essence, AR activators can be viewed as the keys that unlock the AR's biological functions. These activators include both naturally occurring and synthetic compounds. Naturally occurring AR activators are primarily the androgens themselves, like testosterone and DHT. Synthetic AR activators, on the other hand, can come in various forms, often designed to either mimic the action of androgens or modulate AR activity in unique ways.

The mechanism of action for AR activators typically involves binding to the androgen receptor, which leads to a conformational change in the receptor. This change allows the AR to translocate to the cell nucleus, where it binds to specific regions of DNA known as androgen response elements (AREs). Binding to AREs facilitates the recruitment of other proteins and the initiation of transcription, the first step in gene expression. The specific genes that are transcribed depend on the cell type and context, but they generally encode for proteins that mediate the cellular effects of androgens. These effects can include cell growth and differentiation, protein synthesis, and other metabolic processes. Importantly, the activity of AR activators is modulated by numerous factors, including the local concentration of androgens, the presence of coactivators and corepressors, and post-translational modifications to the AR itself. As such, the biological effects of AR activators can vary widely depending on the specific circumstances.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Danazol

17230-88-5sc-203021
sc-203021A
100 mg
250 mg
$90.00
$233.00
3
(0)

Danazol is a synthetic steroid with weak androgenic activity. It's thought to increase AR expression indirectly through its effects on hormone levels.

DHEA

53-43-0sc-202573
10 g
$109.00
3
(1)

DHEA is a natural steroid hormone that can be converted into androgens in the body, potentially leading to increased AR signaling.

TBTC

1461-22-9sc-251105
5 g
$47.00
(0)

TBT is an environmental pollutant that has been shown to disrupt endocrine systems. It may indirectly increase AR expression by influencing hormone levels.

Bisphenol A

80-05-7sc-391751
sc-391751A
100 mg
10 g
$300.00
$490.00
5
(0)

BPA is an environmental estrogen that can also interact with androgen and estrogen receptors. It may indirectly influence AR expression.

Methoxychlor

72-43-5sc-253009
100 mg
$36.00
(0)

Methoxychlor is an insecticide that has estrogenic effects and can also interact with androgen receptors. It may influence AR expression indirectly.

Finasteride

98319-26-7sc-203954
50 mg
$103.00
3
(1)

Finasteride is a synthetic drug that inhibits the conversion of testosterone to DHT. By reducing DHT levels, it may indirectly increase the expression of AR.

Dutasteride

164656-23-9sc-207600
10 mg
$167.00
2
(1)

Dutasteride is a synthetic drug that inhibits the conversion of testosterone to DHT. By reducing DHT levels, it may indirectly increase the expression of AR.