Molecular structure of TBTC, CAS Number: 1461-22-9
TBTC (CAS 1461-22-9)
Alternate Names:
Tributylchlorotin; Tributyltin chloride
Application:
TBTC is a useful organometallic for proteomics research
CAS Number:
1461-22-9
Purity:
≥96%
Molecular Weight:
325.51
Molecular Formula:
C12H27ClSn
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
TBTC (Tributyltin chloride) is a useful organometallic for proteomics research. TBTC binds to chloride ions, thereby inducing apoptosis within 3T3-L1 preadipocytes. The apoptosis process involves the mitochondrial membrane potential, a pivotal regulator influencing intracellular Ca2+ concentrations. TBTC has demonstrated its capacity to increase copper-induced cellular toxicity by inhibiting ryanodine receptors. Its solubility spans various solvents, including methanol, ethanol, acetone, benzene, chloroform, hexane, and ether.
TBTC (CAS 1461-22-9) References
- Effects of Tributyltin Chloride on Cybrids with or without an ATP Synthase Pathologic Mutation. | López-Gallardo, E., et al. 2016. Environ Health Perspect. 124: 1399-405. PMID: 27129022
- Tributyltin chloride induces renal dysfunction by inflammation and oxidative stress in female rats. | Coutinho, JV., et al. 2016. Toxicol Lett. 260: 52-69. PMID: 27521499
- Toxic function of CD28 involving in the TLR/MyD88 signal pathway in the river pufferfish (Takifugu obscurus) after exposed to tributyltin chloride (TBT-Cl). | Fang, DA., et al. 2019. Gene. 688: 84-92. PMID: 30529248
- Paeoniflorin inhibits tributyltin chloride-induced apoptosis in hypothalamic neurons via inhibition of MKK4-JNK signaling pathway. | Cong, C., et al. 2019. J Ethnopharmacol. 237: 1-8. PMID: 30878547
- Tributyltin chloride (TBT) induces RXRA down-regulation and lipid accumulation in human liver cells. | Stossi, F., et al. 2019. PLoS One. 14: e0224405. PMID: 31710612
- Effects of tributyltin chloride on cell structures of epithelial layer in different stages of Artemia salina (Linnaeus, 1758). | Abushaala, NM. 2020. Open Vet J. 9: 366-374. PMID: 32042660
- Toll-like receptors (TLRs) respond to tributyltin chloride (TBT-Cl) exposure in the river pufferfish (Takifugu obscurus): Evidences for its toxic injury function. | Zhao, CS., et al. 2020. Fish Shellfish Immunol. 99: 526-534. PMID: 32097718
- Tiao Geng decoction inhibits tributyltin chloride-induced GT1-7 neuronal apoptosis through ASK1/MKK7/JNK signaling pathway. | Li, S., et al. 2021. J Ethnopharmacol. 269: 113669. PMID: 33338591
- Tributyltin chloride exposure to post-ejaculatory sperm reduces motility, mitochondrial function and subsequent embryo development. | Daigneault, BW. and de Agostini Losano, JD. 2022. Reprod Fertil Dev. 34: 833-843. PMID: 35610772
- Toxicity of tributyltin chloride on haarder (Liza haematocheila) after its acute exposure: Bioaccumulation, antioxidant defense, histological, and transcriptional analyses. | Zhao, C., et al. 2022. Fish Shellfish Immunol. 130: 501-511. PMID: 36162773
- Tributyltin chloride (TBTCL) induces cell injury via dysregulation of endoplasmic reticulum stress and autophagy in Leydig cells. | Chen, P., et al. 2023. J Hazard Mater. 448: 130785. PMID: 36860030
- Biochemical mechanisms of tributyltin chloride-induced cell toxicity in Sertoli cells. | Chen, P., et al. 2023. Ecotoxicol Environ Saf. 255: 114725. PMID: 36924558
- Evaluating the histomorphological and biochemical changes induced by Tributyltin Chloride on pituitary-testicular axis of adult albino rats and the possible ameliorative role of hesperidin. | Shaban, SF., et al. 2023. Ultrastruct Pathol. 47: 304-323. PMID: 36988127
Inhibitor of:
Abp δ, F1-ATPase, PTPMT1, and TEX9.Activator of:
Androgen Receptor, GADD 153, IL-3β, scute, Slc16a5, and TSPY2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TBTC, 5 g | sc-251105 | 5 g | $47.00 |