AMIGO3 Activators
AMIGO3 Activators are a carefully curated group of chemical compounds that, each through a unique mechanism, contribute to the enhancement of AMIGO3's cellular function. Forskolin and Rolipram, by driving up intracellular cAMP levels, activate protein kinase A (PKA), which may target AMIGO3 or its interacting partners for phosphorylation, leading to enhanced AMIGO3 signaling. Ionomycin's role in increasing intracellular calcium levels could similarly bolster AMIGO3 activity by activating calmodulin-dependent protein kinases, which may then interact with AMIGO3 directly or its associated proteins. Phorbol 12-myristate 13-acetate (PMA) engages protein kinase C (PKC), a kinase that may phosphorylate AMIGO3, thus positively influencing its activity, while retinoic acid, through gene expression modulation, might upregulate proteins that enhance AMIGO3's function.
Additionally, agents such as 5-Azacytidine and curcumin act at the genomic and proteomic levels respectively, possibly leading to the enhanced expression of proteins that interact with AMIGO3 or modulating the activity of these proteins to favor AMIGO3 activation. Resveratrol and Epigallocatechin gallate (EGCG) are known to affect post-translational modifications of proteins; such modifications could affect AMIGO3 function by impacting the protein complex formations necessary for its activity.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Adenosine 3′,5′-cyclic monophosphate | 60-92-4 | sc-217584 sc-217584A sc-217584B sc-217584C sc-217584D sc-217584E | 100 mg 250 mg 5 g 10 g 25 g 50 g | $116.00 $179.00 $265.00 $369.00 $629.00 $1150.00 | ||
cAMP is a second messenger that increases intracellular signaling by activating protein kinase A (PKA). PKA can phosphorylate specific substrates that may interact with AMIGO3, thereby enhancing AMIGO3's cell signaling roles. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a diacylglycerol analog that activates protein kinase C (PKC). PKC activation can lead to downstream effects that potentiate signaling pathways where AMIGO3 is involved, such as neuronal outgrowth and axon guidance. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing cAMP levels and thereby indirectly enhancing AMIGO3 signaling functions by promoting PKA activity which could phosphorylate proteins that regulate AMIGO3's activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that raises intracellular calcium levels, potentially altering calcium-dependent protein interactions and signaling cascades that can enhance the activity of AMIGO3 in neuronal cells. | ||||||
Spermine | 71-44-3 | sc-212953A sc-212953 sc-212953B sc-212953C | 1 g 5 g 25 g 100 g | $61.00 $196.00 $277.00 $901.00 | 1 | |
Spermine is a polyamine that can modulate ion channels and has been implicated in the modulation of intracellular signaling pathways. These pathways could enhance AMIGO3-mediated processes by affecting cellular adhesion. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG is a catechin found in green tea with kinase inhibitory activity. It may affect signaling pathways indirectly influencing AMIGO3 activity by altering the phosphorylation state of interacting proteins or receptors. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
S1P is a bioactive lipid that activates sphingosine-1-phosphate receptors, which could influence the signaling pathways involving AMIGO3, potentially enhancing its role in neuron-neuron communication. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Brefeldin A disrupts protein trafficking and can indirectly influence signaling pathways that might enhance AMIGO3 activity by modulating its localization and interactions at the cell surface where it functions. | ||||||
Ryanodine | 15662-33-6 | sc-201523 sc-201523A | 1 mg 5 mg | $223.00 $799.00 | 19 | |
Ryanodine affects calcium release channels (ryanodine receptors), which could modulate intracellular calcium signaling pathways, potentially enhancing AMIGO3's activity in processes dependent on calcium signaling. | ||||||