AMAP-1 Activators
AMAP-1, also known as ASAP1 (ArfGAP with SH3 domain, ankyrin repeat, and PH domain 1), is a multifunctional protein that plays a pivotal role in cellular dynamics and architecture. As a GTPase-activating protein (GAP) for the small GTPase Arf1, AMAP-1 regulates the Arf1-mediated remodeling of the actin cytoskeleton, which is crucial for various cellular processes including cell migration, adhesion, and vesicular trafficking.
AMAP-1 is characterized by the presence of several protein interaction domains, including the SH3 domain, the PH domain, and ankyrin repeats. These domains enable AMAP-1 to interact with a wide range of other proteins, thereby integrating signals that coordinate actin dynamics and membrane trafficking. The PH domain, in particular, binds to phospholipids in the cell membrane, which can recruit AMAP-1 to specific cellular locations, especially those undergoing active remodeling.The protein is known to be involved in cancer cell invasiveness, and its expression is upregulated in certain types of cancers, where it has been associated with the progression of the disease. The exact mechanisms by which AMAP-1 contributes to disease progression are still under investigation, but it is believed to involve the modulation of cellular signaling pathways that control cell shape and motility.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride can inhibit GSK-3 activity, potentially impacting gene transcription and cellular processes. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is an activator of protein kinase C which may upregulate genes involved in cell migration. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
Inhibits protein synthesis, leading to compensatory responses in protein expression. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Inhibits mTOR signaling, which can affect protein synthesis and cellular stress responses. | ||||||
Tamoxifen | 10540-29-1 | sc-208414 | 2.5 g | $256.00 | 18 | |
Modulates estrogen receptor activity, potentially influencing gene expression. | ||||||
Bleomycin | 11056-06-7 | sc-507293 | 5 mg | $270.00 | 5 | |
Induces DNA damage, which can lead to cellular stress responses and altered gene expression. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $62.00 $178.00 | 8 | |
Binds to estrogen receptors and may affect gene expression related to cell trafficking. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Stabilizes microtubules, potentially affecting cytoskeleton organization and related gene expression. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Causes ER stress, which may upregulate proteins involved in vesicle trafficking. | ||||||
Adenosine 3′,5′-cyclic monophosphate | 60-92-4 | sc-217584 sc-217584A sc-217584B sc-217584C sc-217584D sc-217584E | 100 mg 250 mg 5 g 10 g 25 g 50 g | $114.00 $175.00 $260.00 $362.00 $617.00 $1127.00 | ||
Acts as a second messenger, potentially enhancing the expression of genes like AMAP-1. | ||||||