α-KGD Activators
The chemical class α-KGD Activators consists of compounds that can indirectly influence the activity of α-Ketoglutarate Dehydrogenase, an enzyme central to the Krebs cycle in cellular metabolism. These activators are not directly interacting with α-KGD but modulate various biochemical and cellular processes that can impact α-KGD activity. Compounds like Coenzyme Q10, Niacin, and Riboflavin play key roles in enhancing mitochondrial function and the synthesis of essential cofactors (NAD+ and FAD) for the Krebs cycle. Their ability to improve mitochondrial efficiency and increase the availability of cofactors can indirectly boost the activity of enzymes like α-KGD in the Krebs cycle. Similarly, Thiamine and Lipoic Acid, as cofactors for metabolic enzymes, can enhance the overall efficiency of carbohydrate metabolism, indirectly affecting α-KGD activity.
Additionally, minerals like Magnesium, Calcium, and Zinc, by acting as cofactors or by influencing cellular processes, can support the optimal function of metabolic enzymes, including α-KGD. For example, adequate magnesium levels are essential for many enzymes in the Krebs cycle, supporting their optimal activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Coenzyme Q10 | 303-98-0 | sc-205262 sc-205262A | 1 g 5 g | $71.00 $184.00 | 1 | |
Coenzyme Q10 is involved in the electron transport chain. Its role in enhancing mitochondrial function may indirectly increase the activity of enzymes in the Krebs cycle, including α-KGD. | ||||||
Nicotinic Acid | 59-67-6 | sc-205768 sc-205768A | 250 g 500 g | $62.00 $124.00 | 1 | |
Niacin, a form of Vitamin B3, is essential for the synthesis of NAD+, a coenzyme in cellular metabolism. Increased NAD+ levels can enhance Krebs cycle activity, potentially influencing α-KGD. | ||||||
Riboflavin | 83-88-5 | sc-205906 sc-205906A sc-205906B | 25 g 100 g 1 kg | $41.00 $112.00 $525.00 | 3 | |
Riboflavin, or Vitamin B2, is crucial for FAD synthesis. FAD is a cofactor in many metabolic reactions, including those in the Krebs cycle, indirectly affecting α-KGD activity. | ||||||
Vitamin B1 | 59-43-8 | sc-338735 | 5 g | $611.00 | ||
Thiamine, or Vitamin B1, is a cofactor for several enzymes in carbohydrate metabolism. Its role in the metabolism can indirectly increase α-KGD activity in the Krebs cycle. | ||||||
α-Lipoic Acid | 1077-28-7 | sc-202032 sc-202032A sc-202032B sc-202032C sc-202032D | 5 g 10 g 250 g 500 g 1 kg | $69.00 $122.00 $212.00 $380.00 $716.00 | 3 | |
Lipoic Acid acts as a cofactor for mitochondrial enzymes, including those in the Krebs cycle. Its supplementation can enhance α-KGD activity indirectly by improving mitochondrial function. | ||||||
Calcium | 7440-70-2 | sc-252536 | 5 g | $209.00 | ||
Calcium ions play a role in many cellular processes, including enzyme activation. Their presence can positively influence metabolic pathways, potentially affecting α-KGD activity. | ||||||
α-Ketoglutaric Acid | 328-50-7 | sc-208504 sc-208504A sc-208504B sc-208504C sc-208504D sc-208504E sc-208504F | 25 g 100 g 250 g 500 g 1 kg 5 kg 16 kg | $33.00 $43.00 $63.00 $110.00 $188.00 $738.00 $2091.00 | 2 | |
Alpha-Ketoglutarate, as a substrate for α-KGD, can influence its activity. Supplementing with alpha-ketoglutarate may increase the availability of the substrate, potentially enhancing α-KGD activity. | ||||||
Creatine, anhydrous | 57-00-1 | sc-214774 sc-214774A | 10 mg 50 g | $28.00 $79.00 | 2 | |
Creatine supplementation can enhance cellular energy stores, indirectly influencing energy metabolism and potentially the activity of enzymes in the Krebs cycle like α-KGD. | ||||||
D-(+)-Biotin | 58-85-5 | sc-204706 sc-204706A sc-204706B | 1 g 5 g 25 g | $41.00 $107.00 $333.00 | 1 | |
Biotin, a B-vitamin, is involved in carboxylation reactions. Its role in metabolic pathways can indirectly influence the function of enzymes in the Krebs cycle, including α-KGD. | ||||||
L-Carnitine | 541-15-1 | sc-205727 sc-205727A sc-205727B sc-205727C | 1 g 5 g 100 g 250 g | $23.00 $34.00 $79.00 $179.00 | 3 | |
Carnitine facilitates the transport of fatty acids into mitochondria for β-oxidation, which can indirectly enhance the activity of Krebs cycle enzymes, including α-KGD. | ||||||