α-Defensin inhibitors represent a class of molecules designed to specifically modulate the activity of α-defensins, which are small cationic peptides that play a crucial role in the innate immune system. α-Defensins are known for their ability to interact with microbial membranes, leading to their disruption through pore formation. This process is facilitated by their amphipathic structure, allowing α-defensins to integrate into lipid bilayers. Inhibitors of α-defensins are typically designed to block these interactions at a molecular level, preventing the peptides from engaging with lipid membranes or other relevant biological structures. These inhibitors can function by binding directly to the active sites of α-defensins or by interacting with specific amino acid residues critical for their biological activity, thereby altering their structural conformation.
The mechanism of action of α-defensin inhibitors can involve complex chemical interactions, such as hydrogen bonding, hydrophobic interactions, or electrostatic forces, depending on the nature of the inhibitor and its target site. These inhibitors are typically composed of small molecules, peptides, or other bioactive compounds with carefully designed structural features that allow them to interact selectively with α-defensins. The study of α-defensin inhibitors provides insights into the fundamental biochemical pathways related to host defense and molecular recognition, offering a deeper understanding of how certain proteins and peptides interact with their molecular targets in a non-pathogenic context. By investigating the structure-activity relationships of these inhibitors, researchers gain valuable information about the precise molecular mechanisms that govern α-defensin activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Glucocorticoid that can suppress inflammation and possibly downregulate α-defensin expression. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
Inhibits TGF-β signaling, potentially affecting α-defensin expression in epithelial cells. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $71.00 $163.00 $296.00 | 2 | |
Known to upregulate α-defensin production in certain contexts, its antagonists could theoretically downregulate it. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Affects differentiation and could modulate α-defensin expression in mucosal tissues. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
Inhibits NF-κB, a factor in the signaling pathway that can induce α-defensin expression. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Could affect the cellular environment and indirectly impact α-defensin expression. | ||||||
Ruxolitinib | 941678-49-5 | sc-364729 sc-364729A sc-364729A-CW | 5 mg 25 mg 25 mg | $251.00 $500.00 $547.00 | 16 | |
May modulate pathways involved in the immune response and α-defensin production. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Modulates chromatin structure and gene expression, potentially affecting α-defensin genes. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
Might modulate inflammatory signaling pathways influencing α-defensin expression. | ||||||