α-actinin-3 Inhibitors
Common α-actinin-3 Inhibitors include, but are not limited to (±)-Blebbistatin CAS 674289-55-5, Cytochalasin D CAS 22144-77-0, Latrunculin A, Latrunculia magnifica CAS 76343-93-6, Jasplakinolide CAS 102396-24-7 and CK 666 CAS 442633-00-3.
α-actinin-3 inhibitors belong to a specific chemical class of compounds designed to target and inhibit the activity of α-actinin-3, a protein primarily expressed in fast-twitch skeletal muscle fibers. α-actinin-3 is part of the α-actinin family of actin-binding proteins that play a role in maintaining the structural integrity of muscle fibers and facilitating muscle contraction. α-actinin-3 deficiency is a genetic trait found in a subset of individuals, leading to variations in muscle performance and athletic abilities.
α-actinin-3 inhibitors work by specifically targeting the α-actinin-3 protein, interfering with its ability to interact with actin filaments and regulate muscle contraction dynamics. By doing so, these inhibitors may influence the biomechanical properties of fast-twitch muscle fibers and impacts muscle performance. Research into α-actinin-3 inhibitors is ongoing to unravel their precise mechanisms of action and explore their implications in understanding muscle physiology and performance. The study of α-actinin-3 inhibitors contributes to a deeper comprehension of the intricate mechanisms governing muscle structure and function.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(±)-Blebbistatin | 674289-55-5 | sc-203532B sc-203532 sc-203532A sc-203532C sc-203532D | 5 mg 10 mg 25 mg 50 mg 100 mg | $183.00 $313.00 $464.00 $942.00 $1723.00 | 7 | |
Blebbistatin is a small molecule inhibitor that interacts with the ATPase domain of α-actinin-3, inhibiting its actin-binding and bundling activity, thereby disrupting its role in crosslinking actin filaments and potentially affecting cell contractility and motility. | ||||||
CK-869 | 388592-44-7 | sc-507274 | 5 mg | $163.00 | ||
CK-869 is a compound that interferes with the actin-binding activity of α-actinin-3, potentially disrupting its involvement in anchoring actin filaments and affecting cellular processes that rely on proper actin organization and dynamics. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
Cytochalasin D disrupts the actin cytoskeleton by binding to actin filaments, which could indirectly affect the binding and function of α-actinin-3 in organizing actin structures and influencing cellular shape and movement. | ||||||
SMIFH2 | 340316-62-3 | sc-507273 | 5 mg | $140.00 | ||
SMIFH2 is known to inhibit formins, which are involved in actin polymerization. Inhibition of formin activity by SMIFH2 could impact the availability of actin filaments for α-actinin-3 to crosslink, thus potentially affecting its cellular functions. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $265.00 $815.00 | 36 | |
Latrunculin compounds sequester actin monomers, preventing their polymerization into filaments. This could indirectly interfere with the substrate available for α-actinin-3 binding, potentially affecting its role in anchoring actin structures. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $184.00 $305.00 | 59 | |
Jasplakinolide is known to promote actin polymerization. Inhibition of actin polymerization by this compound could influence the availability of actin filaments for interaction with α-actinin-3, potentially impacting its cellular functions. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 is a Rho-associated protein kinase (ROCK) inhibitor that could indirectly affect α-actinin-3 function by modulating the actin cytoskeleton and cell contractility pathways, potentially influencing α-actinin-3's role in organizing actin structures. | ||||||
CK 666 | 442633-00-3 | sc-361151 sc-361151A | 10 mg 50 mg | $321.00 $1040.00 | 5 | |
CK-666 is a small molecule inhibitor that affects the Arp2/3 complex-mediated actin polymerization. By influencing actin dynamics, CK-666 could indirectly impact the availability and organization of actin filaments that α-actinin-3 interacts with. | ||||||
Phalloidin | 17466-45-4 | sc-202763 | 1 mg | $234.00 | 33 | |
Phalloidin binds and stabilizes actin filaments, potentially altering the pool of available actin for α-actinin-3 interactions. This could indirectly affect α-actinin-3's role in anchoring and organizing actin structures within cells. | ||||||