ALIEN Activators
ALIEN activators encompass a diverse array of chemical compounds that indirectly augment the functional activity of ALIEN through modulation of various signaling pathways. Compounds like Forskolin and IBMX, which elevate intracellular cAMP levels, and Epigallocatechin gallate (EGCG) that acts as a kinase inhibitor, play crucial roles in altering cellular signaling landscapes to favor the activation of ALIEN. The increase in cAMP levels activates PKA, leading to a cascade of phosphorylation events that may indirectly influence ALIEN's activity by promoting pathways or processes it is involved in. Similarly, EGCG's inhibition of competitive kinases shifts the signaling balance, potentially enhancing the functional role of ALIEN in cellular processes by reducing the interference from other signaling molecules.
Moreover, the use of molecules like PMA and Sphingosine-1-phosphate (S1P) that target PKC and S1P receptors, respectively, along with PI3K inhibitors such as LY294002 and Wortmannin, introduces alterations in cellular signaling that can indirectly benefit ALIEN's functional activity. PMA's activation of PKC and S1P's receptor-mediated signaling lead to modifications in the cellular environment that could support processes ALIEN is implicated in, such as cell survival, proliferation, or migration. In addition, the strategic inhibition of PI3K by LY294002 and Wortmannin, alongside MEK inhibition by U0126, recalibrates cellular signaling networks, potentially enhancing ALIEN's activity by diverting cellular resources and signaling pathways towards those that ALIEN influences, ensuring an optimized environment for ALIEN's functional engagement in the cell.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin raises intracellular cAMP levels, which can enhance ALIEN activity by activating protein kinase A (PKA). PKA phosphorylation can lead to the activation of downstream targets that may include or affect ALIEN indirectly, promoting its functional activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG inhibits several kinases, potentially reducing competitive signaling pathways and indirectly enhancing ALIEN's activity by shifting the balance towards pathways ALIEN is involved in. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX increases cAMP levels by inhibiting phosphodiesterases, thus potentially enhancing ALIEN activity through the same pathway as Forskolin, by indirect activation of PKA and affecting ALIEN's role. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
S1P acts on its receptors to activate intracellular signaling pathways that can lead to the enhancement of ALIEN activity, possibly by affecting cellular processes such as migration or survival in which ALIEN could be involved. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which can modulate numerous signaling pathways. PKC activation might enhance ALIEN's activity by affecting pathways or processes that are regulated by or involve ALIEN. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that can alter signaling pathways, potentially enhancing ALIEN's activity by reducing competitive pathways and focusing cellular responses toward those involving ALIEN. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 inhibits MEK1/2, affecting the MAPK/ERK pathway. By modulating this pathway, U0126 could indirectly enhance ALIEN activity by shifting signaling dynamics in favor of processes ALIEN is implicated in. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin raises intracellular calcium levels by inhibiting the SERCA pump, which could enhance ALIEN activity through calcium-dependent signaling pathways that interact with or affect ALIEN. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates sirtuins and AMPK, potentially enhancing ALIEN activity by influencing energy metabolism and stress responses in ways that favor the functions or pathways involving ALIEN. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 inhibits p38 MAPK, potentially enhancing ALIEN's activity by modulating stress response pathways or other signaling pathways in which ALIEN could play a part. | ||||||