Aldolase Activators
Aldolase Activators encompass a group of chemical compounds that facilitate the enzyme's role in glycolysis and gluconeogenesis by acting as substrates or by modulating related metabolic pathways. Fructose 1,6-bisphosphate and dihydroxyacetone phosphate directly enhance the catalytic activity of Aldolase by serving as substrates for its glycolytic and gluconeogenic reactions, respectively. Glyceraldehyde 3-phosphate and 2,3-bisphosphoglycerate, both products of glycolytic reactions, may serve as feedback activators, indicating the cellular need for increased metabolic throughput and thus stimulating Aldolase function. Magnesium ions are critical for the structural stabilization and catalytic function of Aldolase, and their presence is essential for the enzyme's activity. Beta-mercaptoethanol contributes to maintaining Aldolase in a reduced and active state, ensuring continuous catalytic competence.
The indirect activators, such as ATP and citrate, signal shifts in cellular energy status or glycolytic flux, leading to an adjustment in Aldolase activity to meet metabolic demands. High ATP levels can result in an accumulation of fructose 6-phosphate, which Aldolase then converts to fructose 1,6-bisphosphate, enhancing its activity in the glycolytic pathway. Similarly, the accumulation of NADH suggests a high rate of glycolysis.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
D-Fructose 1,6-bisphosphate sodium salt | 488-69-7 | sc-484714 | 50 g | $304.00 | ||
Fructose 1,6-bisphosphate is a known substrate of Aldolase in the glycolytic pathway. Binding of this compound to Aldolase leads to the catalysis of the substrate into dihydroxyacetone phosphate and glyceraldehyde 3-phosphate, thus enhancing the functional activity of the enzyme. | ||||||
β-Mercaptoethanol | 60-24-2 | sc-202966A sc-202966 | 100 ml 250 ml | $90.00 $120.00 | 10 | |
Beta-mercaptoethanol can protect the thiol groups of cysteine residues in Aldolase from oxidation, maintaining the enzyme in a reduced and active state. This can enhance the functional activity of Aldolase by preserving its catalytic capability. | ||||||
ADP | 58-64-0 | sc-507362 | 5 g | $54.00 | ||
ATP is not a direct activator of Aldolase, but its levels can signal cellular energy status. High ATP levels can decrease the activity of phosphofructokinase, leading to an accumulation of fructose 6-phosphate, which can be converted to fructose 1,6-bisphosphate and enhance Aldolase activity. | ||||||
Fumaric acid | 110-17-8 | sc-250031 sc-250031A sc-250031B sc-250031C | 25 g 100 g 500 g 2.5 kg | $43.00 $57.00 $114.00 $228.00 | ||
Fumarate is part of the tricarboxylic acid (TCA) cycle and can accumulate under certain conditions, such as hypoxia. Accumulation of fumarate can signal a need to enhance glycolytic flux, indirectly upregulating Aldolase activity to compensate for TCA cycle downregulation. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $57.00 $191.00 $302.00 $450.00 $1800.00 $3570.00 $10710.00 | 4 | |
NADH accumulation can signal a high rate of glycolysis and a need for regeneration of NAD+, which can be achieved via lactate dehydrogenase action. This may indirectly enhance Aldolase activity by increasing the flux of glycolysis to replenish NAD+. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Insulin can enhance glucose uptake and utilization, leading to an increase in glycolytic intermediates. This indirectly enhances Aldolase activity by increasing the substrate availability for the glycolytic pathway. | ||||||
Citric Acid, Anhydrous | 77-92-9 | sc-211113 sc-211113A sc-211113B sc-211113C sc-211113D | 500 g 1 kg 5 kg 10 kg 25 kg | $50.00 $110.00 $145.00 $248.00 $598.00 | 1 | |
Citrate can inhibit phosphofructokinase, leading to an accumulation of upstream glycolytic intermediates such as fructose 6-phosphate. This can increase the conversion to fructose 1,6-bisphosphate, thus indirectly enhancing Aldolase activity. | ||||||