ALDH3B2 Inhibitors

ALDH3B2 inhibitors are chemicals poised to inhibit or modulate the function of ALDH3B2, an enzyme from the ALDH family. This enzyme is dedicated to the crucial task of oxidizing aldehydes, making it imperative in managing aldehyde homeostasis in cells. A representative example of these inhibitors is Disulfiram, renowned for its ability to hinder the oxidation of aldehydes by ALDH3B2. Cyanamide operates on a similar premise, targeting ALDH enzymes and, by extension, possibly ALDH3B2.

Daunorubicin, an antineoplastic agent, showcases its versatility by inhibiting ALDH activity, with ALDH3B2 being a potential target. Similarly, 4-Diethylaminobenzaldehyde and its counterpart N,N-diethylaminobenzaldehyde serve as ALDH inhibitors, directly impeding ALDH3B2's enzymatic activity. Chloral hydrate, through its metabolism by ALDH, can saturate the enzyme and potentially limit ALDH3B2's regular function. Citral and Gossypol, both ALDH inhibitors, are proficient at obstructing the enzymatic oxidation of aldehydes by ALDH3B2. An indirect approach is exemplified by Betaine and Omeprazole, which, while not directly inhibiting the enzyme, can influence related pathways and processes, potentially modifying ALDH3B2's function.