ALCAM (Activated Leukocyte Cell Adhesion Molecule), also known as CD166, is a cell surface glycoprotein belonging to the immunoglobulin superfamily. ALCAM plays a significant role in various cellular processes, primarily by mediating cell-cell adhesion and promoting cell migration. In recent years, researchers have explored a chemical class referred to as ALCAM activators. These compounds are designed to modulate the function of ALCAM by enhancing its activity rather than inhibiting it.
ALCAM activators are chemical compounds or biologics that target ALCAM and promote its cellular functions. These activators typically work by interacting with specific regions on ALCAM's extracellular domain, facilitating its interaction with other cell surface molecules or extracellular ligands. By enhancing ALCAM activity, these compounds can potentially influence various physiological and pathological processes where ALCAM-mediated cell adhesion and signaling play a role. ALCAM activators are a subject of research interest, as they provide a means to explore the molecular mechanisms governing cell adhesion, migration, and other cellular events regulated by ALCAM.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
A derivative of Vitamin A, retinoic acid, has been shown to regulate the expression of various genes, and it could have a role in modulating ALCAM. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Known to activate protein kinase C (PKC), PMA might influence post-translational modifications of ALCAM and hence its activity. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $41.00 $84.00 $275.00 | 127 | |
This compound is known to inhibit protein synthesis and could influence the expression and turnover of ALCAM. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $96.00 $264.00 | 2 | |
A calcium ionophore, ionomycin can increase intracellular calcium levels, which might influence the activity of ALCAM through calcium-dependent signaling pathways. | ||||||