Date published: 2026-5-6

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ALCAM Activators

ALCAM (Activated Leukocyte Cell Adhesion Molecule), also known as CD166, is a cell surface glycoprotein belonging to the immunoglobulin superfamily. ALCAM plays a significant role in various cellular processes, primarily by mediating cell-cell adhesion and promoting cell migration. In recent years, researchers have explored a chemical class referred to as ALCAM activators. These compounds are designed to modulate the function of ALCAM by enhancing its activity rather than inhibiting it.

ALCAM activators are chemical compounds or biologics that target ALCAM and promote its cellular functions. These activators typically work by interacting with specific regions on ALCAM's extracellular domain, facilitating its interaction with other cell surface molecules or extracellular ligands. By enhancing ALCAM activity, these compounds can potentially influence various physiological and pathological processes where ALCAM-mediated cell adhesion and signaling play a role. ALCAM activators are a subject of research interest, as they provide a means to explore the molecular mechanisms governing cell adhesion, migration, and other cellular events regulated by ALCAM.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Retinoic Acid, all trans

302-79-4sc-200898
sc-200898A
sc-200898B
sc-200898C
500 mg
5 g
10 g
100 g
$66.00
$325.00
$587.00
$1018.00
28
(1)

A derivative of Vitamin A, retinoic acid, has been shown to regulate the expression of various genes, and it could have a role in modulating ALCAM.

PMA

16561-29-8sc-3576
sc-3576A
sc-3576B
sc-3576C
sc-3576D
1 mg
5 mg
10 mg
25 mg
100 mg
$41.00
$132.00
$214.00
$500.00
$948.00
119
(6)

Known to activate protein kinase C (PKC), PMA might influence post-translational modifications of ALCAM and hence its activity.

Cycloheximide

66-81-9sc-3508B
sc-3508
sc-3508A
100 mg
1 g
5 g
$41.00
$84.00
$275.00
127
(6)

This compound is known to inhibit protein synthesis and could influence the expression and turnover of ALCAM.

Ionomycin, free acid

56092-81-0sc-263405
sc-263405A
1 mg
5 mg
$96.00
$264.00
2
(2)

A calcium ionophore, ionomycin can increase intracellular calcium levels, which might influence the activity of ALCAM through calcium-dependent signaling pathways.