AKAP 14 Inhibitors
The AKAP 14 inhibitors constitute a class of chemicals that function by curtailing the activity of AKAP 14, a scaffolding protein known to interact with and localize protein kinases like PKA and PKC. These inhibitors function through distinct mechanisms to impede the activation and function of AKAP 14. For instance, H-89, KT5720, and PKI 14-22 amide are known inhibitors of PKA, a chief kinase that AKAP 14 binds to and helps localize.
By inhibiting PKA, these compounds can indirectly affect the function of AKAP 14, as AKAP 14's role in signaling is dependent on the presence of active PKA. Onthe other hand, compounds such as Bisindolylmaleimide I, Gö 6983, and Gö 6976 function as inhibitors of PKC, another kinase that AKAP 14 helps to localize.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
A broad-spectrum kinase inhibitor. Given that AKAP 14 binds to PKA and other kinases, Staurosporine's inhibition of these kinases can indirectly impair the function of AKAP 14 by disrupting its role in localizing these kinases. | ||||||
KT 5720 | 108068-98-0 | sc-3538 sc-3538A sc-3538B | 50 µg 100 µg 500 µg | $97.00 $144.00 $648.00 | 47 | |
Another selective PKA inhibitor. By inhibiting PKA, KT5720 can indirectly affect the function of AKAP 14, as AKAP 14's ability to mediate signaling is dependent on the presence of active PKA. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
A potent and selective inhibitor of protein kinase C (PKC), a kinase that AKAP 14 can help localize. By inhibiting PKC, Bisindolylmaleimide I can indirectly affect the function of AKAP 14 by disrupting its role in localizing PKC. | ||||||
Gö 6983 | 133053-19-7 | sc-203432 sc-203432A sc-203432B | 1 mg 5 mg 10 mg | $103.00 $293.00 $465.00 | 15 | |
A broad-spectrum PKC inhibitor. Given AKAP 14's role in localizing PKC, Gö 6983's inhibition of PKC can indirectly impair the function of AKAP 14 by disrupting its role in localizing this kinase. | ||||||
Gö 6976 | 136194-77-9 | sc-221684 | 500 µg | $223.00 | 8 | |
A selective inhibitor of classical PKCs. By inhibiting PKCs, Gö 6976 can indirectly affect the function of AKAP 14 by disrupting its role in localizing these kinases. | ||||||
Ro 31-8220 | 138489-18-6 | sc-200619 sc-200619A | 1 mg 5 mg | $90.00 $240.00 | 17 | |
A potent PKC inhibitor. Given AKAP 14's role in localizing PKC, Ro 31-8220's inhibition of PKC can indirectly impair the function of AKAP 14 by disrupting its role in localizing this kinase. | ||||||
Rp-8-CPT-cAMPS | 129735-01-9 | sc-215821 | 5 µmol | $712.00 | 2 | |
Another competitive antagonist of cAMP. By antagonizing cAMP, Rp-8-CPT-cAMPS can reduce PKA activity and therefore indirectly affect the function of AKAP 14 by disrupting its role in localizing active PKA. | ||||||
PKI (14-22) amide (myristoylated) | 201422-03-9 | sc-471154 | 0.5 mg | $132.00 | 2 | |
A cell-permeable PKA inhibitor. By inhibiting PKA, PKI 14-22 amide, myristoylated can indirectly affect the function of AKAP 14, as AKAP 14's role in signaling is dependent on the presence of active PKA. | ||||||
Rp-8-PIP-cAMPS | 156816-36-3 | sc-391036 | 1 vial | $462.00 | ||
A cAMP antagonist that can reduce PKA activity. By antagonizing cAMP, Rp-8-PIP-cAMPS can indirectly affect the function of AKAP 14 by disrupting its role in localizing active PKA. | ||||||