AIP1 Activators
AIP1 Activators is a broad classification that encompasses various chemical entities that can indirectly influence the activation of DAB2IP, also known as AIP1. These activators are linked to DAB2IP's role as a negative regulator in several key signaling pathways, including Ras-MAPK, PI3K-Akt, and NF-kB pathways. These chemicals do not directly activate DAB2IP. Instead, they act on the aforementioned pathways, which in turn may stimulate an increase in DAB2IP activity via feedback mechanisms aimed at restoring cellular homeostasis.
This category includes a diverse range of chemicals, from growth factors and hormones to ligands, cytokines, endotoxins, antibiotics, tumor promoters, kinase inhibitors, and natural products. For instance, growth factors activate signaling pathways that DAB2IP negatively regulates, potentially leading to increased DAB2IP activity. Hormones like insulin and angiotensin II, ligand like heregulin, and cytokine like TNF-alpha all act in a similar fashion. In another example, kinase inhibitors inhibit components of the signaling pathways that DAB2IP regulates, possibly indirectly upregulating the need for DAB2IP's action.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Binds to the insulin receptor, leading to the activation of the PI3K-Akt pathway. DAB2IP negatively regulates this pathway, so insulin might indirectly increase DAB2IP activity. | ||||||
Angiotensin II, Human | 4474-91-3 | sc-363643 sc-363643A sc-363643B sc-363643C | 1 mg 5 mg 25 mg 100 mg | $51.00 $100.00 $310.00 $690.00 | 3 | |
Activates the angiotensin II type 1 receptor, leading to the activation of NF-kB pathway. DAB2IP negatively regulates this pathway, so angiotensin II might indirectly increase DAB2IP activity. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Activates stress-activated protein kinases, leading to the activation of Ras-MAPK pathway. DAB2IP negatively regulates this pathway, so anisomycin might indirectly increase DAB2IP activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Activates protein kinase C, leading to the activation of Ras-MAPK pathway. DAB2IP negatively regulates this pathway, so PMA might indirectly increase DAB2IP activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
Inhibits PI3K, which is a part of PI3K-Akt pathway. By inhibiting this pathway, LY294002 might indirectly increase the need for DAB2IP's action. | ||||||
Rottlerin | 82-08-6 | sc-3550 sc-3550B sc-3550A sc-3550C sc-3550D sc-3550E | 10 mg 25 mg 50 mg 1 g 5 g 20 g | $84.00 $166.00 $302.00 $2091.00 $5212.00 $16657.00 | 51 | |
Inhibits PKCdelta, which can lead to inhibition of PI3K/Akt signaling. By inhibiting this pathway, rottlerin might indirectly increase the need for DAB2IP's action. | ||||||