AHSP Inhibitors
AHSP inhibitors are chemical compounds that modulate the activity of Alpha-Hemoglobin Stabilizing Protein (AHSP). AHSP is a small molecular chaperone protein found in red blood cells and is involved in the regulation of hemoglobin stability. Hemoglobin is the protein responsible for oxygen transport in the bloodstream, and it comprises four globin subunits. Inhibitors of AHSP are designed to interact with this chaperone protein, potentially disrupting its function and affecting the stability of hemoglobin within red blood cells.
These inhibitors are typically small molecules or compounds that can bind to AHSP, thereby interfering with its ability to interact with hemoglobin. AHSP's role is to prevent the premature precipitation of excess alpha-globin chains, which can lead to the formation of toxic aggregates in red blood cells. By inhibiting AHSP, these inhibitors may disrupt the delicate balance between alpha and beta globin chains in hemoglobin, potentially leading to changes in hemoglobin stability and oxygen-carrying capacity.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $78.00 $260.00 | 18 | |
Hydroxyurea may affect AHSP expression indirectly by altering hemoglobin synthesis and the balance of globin chain production. | ||||||
Butyric acid | 107-92-6 | sc-214640 sc-214640A | 1 kg 10 kg | $64.00 $177.00 | ||
Butyrate, a short-chain fatty acid, has been shown to induce fetal hemoglobin (HbF) production. This could potentially affect AHSP expression by altering the dynamics of globin synthesis. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
Decitabine, a DNA methyltransferase inhibitor, could influence AHSP expression by altering DNA methylation patterns and the transcriptional regulation of genes associated with hemoglobin synthesis. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
Azacitidine, similar to Decitabine, might impact AHSP expression through its action on DNA methylation, affecting the transcriptional regulation of genes involved in hemoglobin synthesis. | ||||||
Lenalidomide | 191732-72-6 | sc-218656 sc-218656A sc-218656B | 10 mg 100 mg 1 g | $50.00 $374.00 $2071.00 | 18 | |
Lenalidomide might influence AHSP expression by modulating erythropoiesis and the balance of globin chain synthesis in red blood cells. | ||||||
Pomalidomide | 19171-19-8 | sc-364593 sc-364593A sc-364593B sc-364593C sc-364593D sc-364593E | 5 mg 10 mg 50 mg 100 mg 500 mg 1 g | $100.00 $143.00 $312.00 $468.00 $1248.00 $1997.00 | 1 | |
Pomalidomide, related to Lenalidomide, could potentially affect AHSP expression by altering erythropoiesis and the regulatory mechanisms of globin gene expression. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin, an mTOR inhibitor, might affect AHSP expression by influencing protein synthesis pathways and cellular stress responses, which can regulate gene expression. | ||||||
Thalidomide | 50-35-1 | sc-201445 sc-201445A | 100 mg 500 mg | $111.00 $357.00 | 8 | |
Thalidomide, through its effects on the degradation of specific transcription factors, might potentially influence AHSP expression by modulating transcriptional control mechanisms. | ||||||
Danazol | 17230-88-5 | sc-203021 sc-203021A | 100 mg 250 mg | $92.00 $238.00 | 3 | |
Danazol might impact AHSP expression by modulating erythropoiesis and the synthesis of globin chains, potentially affecting the balance in hemoglobin assembly. | ||||||