AFAP-1L2 Activators
AFAP-1L2 Activators are compounds that either directly or indirectly influence the functional activity of AFAP-1L2. The primary role of AFAP-1L2 in cells is to link signal transduction to actin filament organization, which is critical for various cellular processes, including movement, division, and maintaining cell shape. Compounds such as PIP2 and Arachidonic acid play roles in modulating the cytoskeletal dynamics and actin filament organization, which are fundamental to the activity of AFAP-1L2. PIP2 directly affects the actin-binding affinity, while Arachidonic acid promotes the association of AFAP-1L2 with actin filaments, thus influencing the cytoskeletal organization.
Other activators, such as Lysophosphatidic acid (LPA) and EpiderAFAP-1L2 Activators are compounds that either directly or indirectly influence the functional activity of AFAP-1L2. The primary role of AFAP-1L2 in cells is to link signal transduction to actin filament organization, which is critical for various cellular processes, including movement, division, and maintaining cell shape. Compounds such as PIP2 and Arachidonic acid play roles in modulating the cytoskeletal dynamics and actin filament organization, which are fundamental to the activity of AFAP-1L2. PIP2 directly affects the actin-binding affinity, while Arachidonic acid promotes the association of AFAP-1L2 with actin filaments, thus influencing the cytoskeletal organization.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Arachidonic Acid (20:4, n-6) | 506-32-1 | sc-200770 sc-200770A sc-200770B | 100 mg 1 g 25 g | $92.00 $240.00 $4328.00 | 9 | |
Arachidonic acid is released from membrane phospholipids and is involved in the activation of signaling pathways. It can enhance the activity of AFAP-1L2 by promoting its association with actin filaments, leading to changes in cytoskeletal organization. | ||||||
Lysophosphatidic Acid | 325465-93-8 | sc-201053 sc-201053A | 5 mg 25 mg | $98.00 $341.00 | 50 | |
LPA acts on its receptors to stimulate Rho GTPase signaling, which is involved in the regulation of the actin cytoskeleton. AFAP-1L2, being associated with actin dynamics, can be functionally activated by the downstream effects of LPA-mediated Rho signaling. | ||||||
Calmodulin (human), (recombinant) | 73298-54-1 | sc-471287 | 1 mg | $300.00 | ||
Calmodulin binds to calcium ions and changes its conformation, interacting with various target proteins. It can enhance AFAP-1L2 activity by affecting the calcium/calmodulin-dependent protein kinase pathways that modulate cytoskeletal rearrangement. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Phorbol esters activate protein kinase C (PKC), which can phosphorylate AFAP-1L2 or its associated proteins, enhancing AFAP-1L2-mediated linkage between protein kinase signaling and actin filament organization. | ||||||
NSC 23766 | 733767-34-5 | sc-204823 sc-204823A | 10 mg 50 mg | $151.00 $609.00 | 75 | |
Rac1 is a member of the Rho family of GTPases and regulates the actin cytoskeleton. Activation of Rac1 can enhance AFAP-1L2 functionality by promoting actin polymerization and signaling pathways that AFAP-1L2 is involved in. | ||||||
Calpeptin | 117591-20-5 | sc-202516 sc-202516A | 10 mg 50 mg | $121.00 $456.00 | 28 | |
Cdc42 is another Rho GTPase that, when activated, can promote cytoskeletal reorganization. This enhances AFAP-1L2 activity by facilitating its role in linking actin dynamics to signaling pathways. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing cAMP levels which can lead to PKA activation. PKA phosphorylation can enhance AFAP-1L2's role in actin filament organization and signal transduction. | ||||||
Thrombin from human plasma | 9002-04-4 | sc-471713 | 100 U | $235.00 | ||
Thrombin is a serine protease that can activate platelets and lead to actin polymerization. This can enhance AFAP-1L2's activity by promoting its association with newly formed actin filaments in platelets. | ||||||