AdSS1 Activators
AdSS1 activators belong to a class of chemical compounds designed to modulate the activity of AdSS1, which stands for Adenylosuccinate Synthetase 1. Adenylosuccinate synthetases are enzymes that play a pivotal role in the de novo synthesis of adenosine monophosphate (AMP), a critical component of nucleotide metabolism. AMP is one of the building blocks of RNA and DNA and serves as an essential molecule for various cellular processes, including energy transfer and signal transduction. AdSS1 is responsible for catalyzing the conversion of inosine monophosphate (IMP) and aspartate into adenylosuccinate, a key intermediate in the biosynthesis of AMP.
AdSS1 activators are specifically designed to interact with AdSS1 and potentially enhance its enzymatic activity. By targeting AdSS1, these compounds may modulate the rate of AMP production, which, in turn, can impact cellular nucleotide levels and various cellular processes dependent on AMP. Research on AdSS1 activators provides insights into the intricate mechanisms governing nucleotide metabolism and cellular energy homeostasis. Understanding the molecular interactions between AdSS1 and its activators is crucial for deciphering the complex processes that underlie nucleotide synthesis and its broader implications for cell biology. Further investigation is necessary to elucidate the precise mechanisms of action and potential biological consequences associated with AdSS1 activation, contributing to our knowledge of nucleotide metabolism and cellular physiology.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
AICAR is an analog of AMP that can activate AMP-activated protein kinase (AMPK), potentially increasing AdSS1 expression in response to energy stress. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylate cyclase, increasing cAMP levels and potentially upregulating AdSS1 through cAMP response element-binding (CREB) proteins. | ||||||
Glucagon trifluoroacetic acid salt | 9007-92-5 (free base) | sc-495801 | 1 mg | $480.00 | ||
Glucagon raises cAMP levels in the liver and may stimulate AdSS1 expression as part of the gluconeogenesis pathway. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Insulin can modulate multiple metabolic pathways, potentially increasing AdSS1 expression to meet the nucleotide demand for increased protein synthesis. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $78.00 $260.00 | 18 | |
Hydroxyurea inhibits ribonucleotide reductase, leading to imbalances in nucleotide pools that could upregulate AdSS1 to restore balance. | ||||||
L-Leucine | 61-90-5 | sc-364173 sc-364173A | 25 g 100 g | $21.00 $62.00 | ||
An essential amino acid that can activate the mTOR pathway, which is involved in protein synthesis and may upregulate nucleotide biosynthesis enzymes like AdSS1. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $55.00 $125.00 | 13 | |
This thiazolidinedione can influence the metabolism of nucleotides and potentially upregulate AdSS1 as part of its action on insulin sensitization. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid affects cell differentiation and proliferation, processes that may require increased purine synthesis, thus possibly upregulating AdSS1. | ||||||
Folic Acid | 59-30-3 | sc-204758 | 10 g | $73.00 | 2 | |
Folate is involved in one-carbon metabolism and nucleotide biosynthesis; its availability could influence AdSS1 expression to maintain purine nucleotide levels. | ||||||