ACSVL1 Activators
ACSVL1 activators represent a distinct group of compounds that engage the enzymatic activity of Acyl-CoA Synthetase Very-Long-Chain Family Member 1 (ACSVL1), also known as Fatty Acid Transport Protein 5 (FATP5). ACSVL1 is an enzyme that plays a pivotal role in lipid metabolism by catalyzing the conversion of free long-chain fatty acids into fatty acyl-CoA esters, thereby facilitating their subsequent utilization or storage within the cell. The protein is integral to the process of fatty acid activation, a biochemical step essential for the breakdown or synthesis of lipids.
Activators of ACSVL1 may operate through direct interaction with the enzyme, leading to an increase in its catalytic efficiency. Such compounds could bind to allosteric sites on the enzyme, triggering a conformational alteration that enhances its affinity for fatty acid substrates or its ability to convert these substrates into their activated CoA forms. The activation may also involve the stabilization of the ACSVL1 protein structure in a state that is more conducive to the execution of its enzymatic function. Indirect activators, conversely, might not bind to ACSVL1 directly but can augment its activity by modulating the expression levels of the protein, influencing the transcriptional or translational mechanisms that govern its synthesis. Alternatively, they might impact the post-translational modifications that affect the enzyme's stability and function, such as phosphorylation or ubiquitination. The cellular abundance of fatty acids, which are substrates for ACSVL1, can also be indirectly manipulated by activators that affect the uptake or release of fatty acids by the cell, thereby indirectly modulating ACSVL1 activity by increasing substrate availability.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Arachidonic Acid (20:4, n-6) | 506-32-1 | sc-200770 sc-200770A sc-200770B | 100 mg 1 g 25 g | $92.00 $240.00 $4328.00 | 9 | |
Arachidonic acid is a precursor for eicosanoids, which are signaling molecules. ACSVL1 can enhance the availability of arachidonic acid for eicosanoid biosynthesis. Therefore, arachidonic acid can enhance the functional activity of ACSVL1. | ||||||
Oleic Acid | 112-80-1 | sc-200797C sc-200797 sc-200797A sc-200797B | 1 g 10 g 100 g 250 g | $37.00 $104.00 $580.00 $1196.00 | 10 | |
Oleic acid is a monounsaturated fatty acid taken up by cells and transported into mitochondria, a process facilitated by ACSVL1. Increased availability of oleic acid can enhance the functional activity of ACSVL1. | ||||||
Palmitic Acid | 57-10-3 | sc-203175 sc-203175A | 25 g 100 g | $114.00 $286.00 | 2 | |
Palmitic acid is a common saturated fatty acid used in the body for energy production. ACSVL1 plays a role in the uptake and transport of fatty acids like palmitic acid. Thus, palmitic acid can enhance the functional activity of ACSVL1. | ||||||
Stearic Acid | 57-11-4 | sc-203408 sc-203408A sc-203408B | 100 g 1 kg 5 kg | $26.00 $32.00 $117.00 | 1 | |
Stearic acid is a long-chain fatty acid that is incorporated into complex lipids. ACSVL1 is involved in the cellular uptake and transport of stearic acid, so it can enhance the functional activity of ACSVL1. | ||||||
Linoleic Acid | 60-33-3 | sc-200788 sc-200788A sc-200788B sc-200788C | 100 mg 1 g 5 g 25 g | $34.00 $64.00 $166.00 $281.00 | 4 | |
Linoleic acid is an essential fatty acid that must be obtained from the diet. ACSVL1 is involved in the transport of fatty acids like linoleic acid, so it can enhance the functional activity of ACSVL1. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone is a glucocorticoid that can upregulate the expression of genes involved in fatty acid metabolism, including ACSVL1. This steroid hormone can enhance the functional activity of ACSVL1 by promoting its fatty acid transport function. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Insulin enhances the uptake and utilization of fatty acids in cells. ACSVL1 plays a key role in these processes, so insulin can enhance the functional activity of ACSVL1. | ||||||
Triacsin C Solution in DMSO | 76896-80-5 | sc-200574 sc-200574A | 100 µg 1 mg | $187.00 $843.00 | 14 | |
Triacsin C is an inhibitor of long-chain acyl-CoA synthetases. By inhibiting these enzymes, triacsin C can enhance the functional activity of ACSVL1 by increasing the availability of free fatty acids for its action. | ||||||
TOFA (5-(Tetradecyloxy)-2-furoic acid) | 54857-86-2 | sc-200653 sc-200653A | 10 mg 50 mg | $97.00 $374.00 | 15 | |
TOFA is an inhibitor of acetyl-CoA carboxylase, which prevents the conversion of acetyl-CoA to malonyl-CoA. This process can enhance the functional activity of ACSVL1 by increasing the availability of acetyl-CoA, a substrate in fatty acid metabolism. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
AICAR is an activator of AMP-activated protein kinase (AMPK), which can upregulate fatty acid oxidation processes. ACSVL1 is involved in these processes, so AICAR can enhance the functional activity of ACSVL1. | ||||||