Date published: 2025-9-5

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ACSL4 Activators

ACSL4 Activators, also known as Acyl-CoA Synthetase Long Chain Family Member 4 Activators, belong to a specific category of chemical compounds that play a crucial role in modulating the activity of the ACSL4 enzyme. The ACSL4 enzyme, found in various tissues throughout the body, is a key player in lipid metabolism and cellular homeostasis. It primarily functions by catalyzing the esterification of long-chain fatty acids with coenzyme A (CoA), a crucial step in the intracellular handling of fatty acids. ACSL4 Activators are molecules that enhance the activity of this enzyme, promoting the conversion of fatty acids into their CoA-bound form. This activation is a pivotal step in the metabolism of lipids, as it facilitates their incorporation into various cellular processes, including energy production and membrane structure.

The regulation of ACSL4 activity through its activators is essential for several physiological processes, such as lipid storage, energy production, and membrane synthesis. These compounds act as molecular switches that fine-tune the cellular response to changes in lipid availability and demand. In this context, ACSL4 Activators can play a role in maintaining cellular homeostasis and adapting to various metabolic conditions. Understanding the mechanisms and implications of ACSL4 activation is of significant interest in the field of cellular biology and metabolism, as it sheds light on how cells manage their lipid resources and adapt to different physiological states. Research into ACSL4 Activators continues to uncover their role in lipid metabolism and their potential impact on various cellular processes.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Rosiglitazone

122320-73-4sc-202795
sc-202795A
sc-202795C
sc-202795D
sc-202795B
25 mg
100 mg
500 mg
1 g
5 g
$118.00
$320.00
$622.00
$928.00
$1234.00
38
(1)

Rosiglitazone is a PPARγ agonist that may enhance ACSL4 expression, as ACSL4 is a target gene of PPARγ, playing a role in fatty acid metabolism and adipogenesis.

Palmitic Acid

57-10-3sc-203175
sc-203175A
25 g
100 g
$112.00
$280.00
2
(0)

Palmitic acid, a saturated fatty acid, could potentially upregulate ACSL4 to facilitate its own metabolism and incorporation into complex lipids.

Oleic Acid

112-80-1sc-200797C
sc-200797
sc-200797A
sc-200797B
1 g
10 g
100 g
250 g
$36.00
$102.00
$569.00
$1173.00
10
(1)

Oleic acid, a monounsaturated fatty acid, might increase ACSL4 expression to promote its utilization in lipid biosynthesis and energy production.

Arachidonic Acid (20:4, n-6)

506-32-1sc-200770
sc-200770A
sc-200770B
100 mg
1 g
25 g
$90.00
$235.00
$4243.00
9
(1)

As a polyunsaturated fatty acid, arachidonic acid may specifically induce ACSL4, given the enzyme’s preference for polyunsaturated substrates.

Insulin

11061-68-0sc-29062
sc-29062A
sc-29062B
100 mg
1 g
10 g
$153.00
$1224.00
$12239.00
82
(1)

Insulin can influence lipid metabolism and may upregulate ACSL4 expression to enhance fatty acid utilization and storage, particularly in adipose tissue.

D(+)Glucose, Anhydrous

50-99-7sc-211203
sc-211203B
sc-211203A
250 g
5 kg
1 kg
$37.00
$194.00
$64.00
5
(1)

Elevated glucose levels might stimulate ACSL4 expression to manage increased demands for lipid synthesis and energy production.

Retinoic Acid, all trans

302-79-4sc-200898
sc-200898A
sc-200898B
sc-200898C
500 mg
5 g
10 g
100 g
$65.00
$319.00
$575.00
$998.00
28
(1)

Retinoic acid regulates gene expression and cellular differentiation, and it may influence ACSL4 expression in the context of lipid metabolism and cell development.