ACSL4 Antibody (F-4): sc-365230
- ACSL4 Antibody (F-4) is a mouse monoclonal IgG1 κ ACSL4 antibody, cited in 87 publications, provided at 200 µg/ml
- raised against amino acids 623-675 mapping near the C-terminus of ACSL4 of human origin
- ACSL4 Antibody (F-4) is recommended for detection of short isoform and long isoform of ACSL4 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-ACSL4 Antibody (F-4) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for ACSL4 Antibody (F-4) for WB and IHC(P) applications. These reagents are now offered in bundles with ACSL4 Antibody (F-4) (see ordering information below).
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ACSL4 Antibody (F-4) is a mouse monoclonal IgG1 kappa light chain antibody that detects ACSL4 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). ACSL4 (F-4) antibody is available in both non-conjugated and multiple conjugated forms, such as agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and various Alexa Fluor® conjugates. ACSL4, a member of the acyl-CoA synthetase family, plays a crucial role in lipid metabolism by catalyzing the conversion of long-chain fatty acids into acyl-CoA derivatives, which are essential for cellular lipid synthesis and energy production through β-oxidation. ACSL4 is predominantly localized in mitochondria, microsomes, and peroxisomes, highlighting ACSL4′s importance in cellular energy homeostasis and lipid biosynthesis. ACSL4 is particularly abundant in steroidogenic tissues, where ACSL4 may influence female fertility and uterine prostaglandin production, underscoring potential implications in reproductive health. Anti-ACSL4 antibody (F-4) serves as a valuable tool for researchers studying metabolic pathways, particularly given ACSL4′s specialized function in utilizing specific fatty acids like arachidonate.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
ACSL4 Antibody (F-4) References:
- Ischemia-induced ACSL4 activation contributes to ferroptosis-mediated tissue injury in intestinal ischemia/reperfusion. | Li, Y., et al. 2019. Cell Death Differ. 26: 2284-2299. PMID: 30737476
- ACSL4 reprograms fatty acid metabolism in hepatocellular carcinoma via c-Myc/SREBP1 pathway. | Chen, J., et al. 2021. Cancer Lett. 502: 154-165. PMID: 33340617
- Isorhapontigenin Attenuates Cardiac Microvascular Injury in Diabetes via the Inhibition of Mitochondria-Associated Ferroptosis Through PRDX2-MFN2-ACSL4 Pathways. | Chen, Y., et al. 2023. Diabetes. 72: 389-404. PMID: 36367849
- ACSL3 and ACSL4, Distinct Roles in Ferroptosis and Cancers. | Yang, Y., et al. 2022. Cancers (Basel). 14: PMID: 36497375
- Calycosin decreases cerebral ischemia/reperfusion injury by suppressing ACSL4-dependent ferroptosis. | Liu, H., et al. 2023. Arch Biochem Biophys. 734: 109488. PMID: 36516890
- ACSL4: biomarker, mediator and target in quadruple negative breast cancer. | Monaco, ME. 2023. Oncotarget. 14: 563-575. PMID: 37306503
- ACSL4 promotes ferroptosis and M1 macrophage polarization to regulate the tumorigenesis of nasopharyngeal carcinoma. | Chen, P., et al. 2023. Int Immunopharmacol. 122: 110629. PMID: 37451020
- STING/ACSL4 axis-dependent ferroptosis and inflammation promote hypertension-associated chronic kidney disease. | Gao, L., et al. 2023. Mol Ther. 31: 3084-3103. PMID: 37533255
- EGCG attenuated acute myocardial infarction by inhibiting ferroptosis via miR-450b-5p/ACSL4 axis. | Yu, Q., et al. 2023. Phytomedicine. 119: 154999. PMID: 37597361
- Vitamin D Attenuates Ulcerative Colitis by Inhibiting ACSL4-Mediated Ferroptosis. | Gao, S., et al. 2023. Nutrients. 15: PMID: 38004239
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ACSL4 Antibody (F-4) | sc-365230 | 200 µg/ml | $322.00 | |||
ACSL4 Antibody (F-4): m-IgG Fc BP-HRP Bundle | sc-529332 | 200 µg Ab; 10 µg BP | $361.00 | |||
ACSL4 Antibody (F-4): m-IgGκ BP-HRP Bundle | sc-522169 | 200 µg Ab, 40 µg BP | $361.00 | |||
ACSL4 Antibody (F-4): m-IgG1 BP-HRP Bundle | sc-543464 | 200 µg Ab; 20 µg BP | $361.00 | |||
ACSL4 Antibody (F-4) AC | sc-365230 AC | 500 µg/ml, 25% agarose | $424.00 | |||
ACSL4 Antibody (F-4) HRP | sc-365230 HRP | 200 µg/ml | $322.00 | |||
ACSL4 Antibody (F-4) FITC | sc-365230 FITC | 200 µg/ml | $336.00 | |||
ACSL4 Antibody (F-4) PE | sc-365230 PE | 200 µg/ml | $349.00 | |||
ACSL4 Antibody (F-4) Alexa Fluor® 488 | sc-365230 AF488 | 200 µg/ml | $364.00 | |||
ACSL4 Antibody (F-4) Alexa Fluor® 546 | sc-365230 AF546 | 200 µg/ml | $364.00 | |||
ACSL4 Antibody (F-4) Alexa Fluor® 594 | sc-365230 AF594 | 200 µg/ml | $364.00 | |||
ACSL4 Antibody (F-4) Alexa Fluor® 647 | sc-365230 AF647 | 200 µg/ml | $364.00 | |||
ACSL4 Antibody (F-4) Alexa Fluor® 680 | sc-365230 AF680 | 200 µg/ml | $364.00 | |||
ACSL4 Antibody (F-4) Alexa Fluor® 790 | sc-365230 AF790 | 200 µg/ml | $364.00 |