ACOT2 Inhibitors
Chemicals classified as ACOT2 inhibitors work indirectly by modulating the availability or synthesis of acyl-CoA substrates, affecting the balance of free fatty acids, or altering the expression and activity of enzymes involved in fatty acid metabolism. Triacsin C, for instance, targets long-chain acyl-CoA synthetase, reducing the pool of acyl-CoAs that serve as substrates for ACOT2. Etomoxir and perhexiline obstruct the entry of fatty acyl-CoAs into mitochondria by inhibiting CPT1, thereby potentially decreasing the substrate availability for ACOT2.
On the other hand, metabolic regulators such as malonyl-CoA, hydroxycitrate, and oxfenicine impact the synthesis and utilization of acyl-CoA. Malonyl-CoA is a known allosteric inhibitor of fatty acid oxidation, which may lead to an accumulation of acyl-CoAs, and hydroxycitrate hinders the production of cytosolic acetyl-CoA by inhibiting ATP-citrate lyase. Compounds like thiazolidinediones (e.g., rosiglitazone) and fibrate drugs (fenofibrate and gemfibrozil) activate peroxisome proliferator-activated receptors (PPARs), which influence the transcription of genes involved in fatty acid transport, trapping, and oxidation, subsequently affecting the levels of acyl-CoAs and the activity of ACOT2. Rimonabant increases AMP levels activating AMPK, which can suppress acyl-CoA synthesis, while nicotinic acid reduces the concentration of free fatty acids available for acyl-CoA formation. Curcumin, with its broad effects on cell signaling and metabolism, may also lead to changes
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Triacsin C Solution in DMSO | 76896-80-5 | sc-200574 sc-200574A | 100 µg 1 mg | $187.00 $843.00 | 14 | |
Inhibits long-chain acyl-CoA synthetase, reducing the acyl-CoA substrate pool for ACOT2. | ||||||
(+)-Etomoxir sodium salt | 828934-41-4 | sc-215009 sc-215009A | 5 mg 25 mg | $151.00 $506.00 | 3 | |
Blocks the activity of CPT1, decreasing fatty acyl-CoA entry into mitochondria, thus may reduce ACOT2 substrate levels. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $120.00 $326.00 $634.00 $947.00 $1259.00 | 38 | |
Activates PPAR-gamma which can upregulate fatty acid uptake and trapping by adipocytes, potentially reducing acyl-CoA levels available to ACOT2. | ||||||
Indole-3-carbinol | 700-06-1 | sc-202662 sc-202662A sc-202662B sc-202662C sc-202662D | 1 g 5 g 100 g 250 g 1 kg | $39.00 $61.00 $146.00 $312.00 $1032.00 | 5 | |
Inhibits carnitine acetyltransferase, which could lead to altered acyl-CoA levels thus indirectly affecting ACOT2. | ||||||
Rimonabant Hydrochloride | 158681-13-1 | sc-212786 | 10 mg | $166.00 | 1 | |
Can increase cellular AMP levels which activate AMPK, leading to downstream effects that may reduce acyl-CoA levels and influence ACOT2 activity. | ||||||
Nicotinic Acid | 59-67-6 | sc-205768 sc-205768A | 250 g 500 g | $62.00 $124.00 | 1 | |
Lowers free fatty acids in plasma, which may reduce acyl-CoA synthesis and thus impact ACOT2 activity. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Influences multiple cell signaling pathways and may affect ACOT2 activity by altering fatty acid metabolism. | ||||||
Fenofibrate | 49562-28-9 | sc-204751 | 5 g | $41.00 | 9 | |
Activates PPAR-alpha, leading to increased beta-oxidation which can alter the balance of acyl-CoAs and potentially affect ACOT2. | ||||||
Gemfibrozil | 25812-30-0 | sc-204764 sc-204764A | 5 g 25 g | $66.00 $267.00 | 2 | |
Similar to fenofibrate, activates PPAR-alpha which could influence ACOT2 activity by changing acyl-CoA levels. | ||||||