Date published: 2025-10-17

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Acnat1 Activators

ACNAT1 Activators are a diverse chemical class that can influence the enzymatic activity of ACNAT1 through a variety of metabolic and regulatory pathways. The mechanisms by which these activators operate involve alterations in the cellular concentrations of substrates, coenzymes, and intermediates that are integral to ACNAT1 function. By modulating the availability of these molecules, ACNAT1 Activators can enhance the enzyme's ability to catalyze its specific reaction. Some activators work by increasing the levels of acyl-CoA, the substrate of ACNAT1, thereby promoting a more favorable environment for the enzyme's action. Others may act indirectly by upregulating pathways that increase the demand for ACNAT1's product, thereby stimulating the enzyme to meet this heightened metabolic need.

Additionally, certain ACNAT1 Activators can affect the enzyme's activity by interacting with regulatory systems that control cellular metabolism. For instance, they can activate signaling pathways that lead to an upsurge in nutrient uptake, which in turn can increase the availability of ACNAT1 substrates within the cell. Some can influence the expression of genes that encode for proteins involved in fatty acid and amino acid metabolism, leading to an indirect upregulation of ACNAT1 activity. These activators can also alter the energy status of the cell, such as by influencing AMPK activity, which can cause a cascade of metabolic changes conducive to the activation of ACNAT1. Through these multifaceted mechanisms, ACNAT1 Activators can modulate the enzyme's function and play a role in the complex network of metabolic regulation.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Pioglitazone

111025-46-8sc-202289
sc-202289A
1 mg
5 mg
$54.00
$123.00
13
(1)

As a PPARγ agonist, pioglitazone can modulate lipid metabolism which can alter acyl-CoA levels, potentially affecting ACNAT1 activity.

AICAR

2627-69-2sc-200659
sc-200659A
sc-200659B
50 mg
250 mg
1 g
$60.00
$270.00
$350.00
48
(2)

This AMPK activator can alter cellular energy balance, which can influence metabolic pathways and can affect ACNAT1 activity.

Rapamycin

53123-88-9sc-3504
sc-3504A
sc-3504B
1 mg
5 mg
25 mg
$62.00
$155.00
$320.00
233
(4)

As an mTOR inhibitor, rapamycin can alter protein and lipid synthesis pathways, which can change substrate availability for ACNAT1.

Triacsin C Solution in DMSO

76896-80-5sc-200574
sc-200574A
100 µg
1 mg
$149.00
$826.00
14
(1)

This acyl-CoA synthetase inhibitor can alter the balance of acyl-CoA substrates available, which can affect ACNAT1 activity.

Cerulenin (synthetic)

17397-89-6sc-200827
sc-200827A
sc-200827B
5 mg
10 mg
50 mg
$158.00
$306.00
$1186.00
9
(1)

Inhibiting fatty acid synthase with cerulenin can reduce the production of fatty acids, potentially affecting ACNAT1 substrate availability.

Gabapentin

60142-96-3sc-201481
sc-201481A
sc-201481B
20 mg
100 mg
1 g
$52.00
$92.00
$132.00
7
(1)

As an inhibitor of an amino acid transport system, gabapentin can affect intracellular amino acid concentrations, which can affect ACNAT1.

Resveratrol

501-36-0sc-200808
sc-200808A
sc-200808B
100 mg
500 mg
5 g
$60.00
$185.00
$365.00
64
(2)

As a sirtuin activator, resveratrol can influence metabolic regulation, potentially altering ACNAT1 activity.

(+)-Etomoxir sodium salt

828934-41-4sc-215009
sc-215009A
5 mg
25 mg
$148.00
$496.00
3
(2)

By inhibiting CPT-1, etomoxir can alter fatty acid oxidation, potentially influencing ACNAT1 activity.