ACNAT1 Activators are a diverse chemical class that can influence the enzymatic activity of ACNAT1 through a variety of metabolic and regulatory pathways. The mechanisms by which these activators operate involve alterations in the cellular concentrations of substrates, coenzymes, and intermediates that are integral to ACNAT1 function. By modulating the availability of these molecules, ACNAT1 Activators can enhance the enzyme's ability to catalyze its specific reaction. Some activators work by increasing the levels of acyl-CoA, the substrate of ACNAT1, thereby promoting a more favorable environment for the enzyme's action. Others may act indirectly by upregulating pathways that increase the demand for ACNAT1's product, thereby stimulating the enzyme to meet this heightened metabolic need.
Additionally, certain ACNAT1 Activators can affect the enzyme's activity by interacting with regulatory systems that control cellular metabolism. For instance, they can activate signaling pathways that lead to an upsurge in nutrient uptake, which in turn can increase the availability of ACNAT1 substrates within the cell. Some can influence the expression of genes that encode for proteins involved in fatty acid and amino acid metabolism, leading to an indirect upregulation of ACNAT1 activity. These activators can also alter the energy status of the cell, such as by influencing AMPK activity, which can cause a cascade of metabolic changes conducive to the activation of ACNAT1. Through these multifaceted mechanisms, ACNAT1 Activators can modulate the enzyme's function and play a role in the complex network of metabolic regulation.
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Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
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Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $54.00 $123.00 | 13 | |
As a PPARγ agonist, pioglitazone can modulate lipid metabolism which can alter acyl-CoA levels, potentially affecting ACNAT1 activity. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $60.00 $270.00 $350.00 | 48 | |
This AMPK activator can alter cellular energy balance, which can influence metabolic pathways and can affect ACNAT1 activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
As an mTOR inhibitor, rapamycin can alter protein and lipid synthesis pathways, which can change substrate availability for ACNAT1. | ||||||
Triacsin C Solution in DMSO | 76896-80-5 | sc-200574 sc-200574A | 100 µg 1 mg | $149.00 $826.00 | 14 | |
This acyl-CoA synthetase inhibitor can alter the balance of acyl-CoA substrates available, which can affect ACNAT1 activity. | ||||||
Cerulenin (synthetic) | 17397-89-6 | sc-200827 sc-200827A sc-200827B | 5 mg 10 mg 50 mg | $158.00 $306.00 $1186.00 | 9 | |
Inhibiting fatty acid synthase with cerulenin can reduce the production of fatty acids, potentially affecting ACNAT1 substrate availability. | ||||||
Gabapentin | 60142-96-3 | sc-201481 sc-201481A sc-201481B | 20 mg 100 mg 1 g | $52.00 $92.00 $132.00 | 7 | |
As an inhibitor of an amino acid transport system, gabapentin can affect intracellular amino acid concentrations, which can affect ACNAT1. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
As a sirtuin activator, resveratrol can influence metabolic regulation, potentially altering ACNAT1 activity. | ||||||
(+)-Etomoxir sodium salt | 828934-41-4 | sc-215009 sc-215009A | 5 mg 25 mg | $148.00 $496.00 | 3 | |
By inhibiting CPT-1, etomoxir can alter fatty acid oxidation, potentially influencing ACNAT1 activity. |