ACAM Activators
ACAM activators encompass a diverse range of chemical compounds that facilitate the enhancement of ACAM's functional activity through various signaling pathways. The activity of ACAM is indirectly augmented by Forskolin and IBMX, both of which elevate intracellular cAMP levels. Forskolin achieves this by direct stimulation of adenylyl cyclase, whereas IBMX inhibits a broad spectrum of phosphodiesterases, preventing cAMP degradation. The resulting increased cAMP activates PKA, which can phosphorylate proteins involved in ACAM-mediated signaling pathways. Similarly, 8-Br-cAMP, a stable cAMP analog, also activates PKA, leading to enhanced ACAM signaling. PMA, through PKC activation, and Ionomycin, by raising intracellular calcium levels, modulate kinases and phosphatases that can influence ACAM activity. These activations suggest that PKC and calcium-dependent kinases could phosphorylate proteins that interact with ACAM, leading to its functional enhancement.
Additionally, compounds such as L-ArginineThe narrative description of ACAM activators is built upon a framework of biochemical interactions that serve to enhance the activity of ACAM through a variety of signaling pathways. Forskolin, by stimulating adenylyl cyclase, and IBMX, by inhibiting phosphodiesterases, both contribute to elevated cAMP levels, which in turn activates PKA. This activation leads to the phosphorylation of proteins that interact with ACAM, enhancing its signaling capabilities. PMA, as an activator of PKC, and Ionomycin, as a calcium ionophore, further contribute to this enhancement by modulating downstream kinases and phosphatases, which could impact ACAM signaling. Compounds like 8-Br-cAMP, a cAMP analog, reinforce this pathway through similar mechanisms, ensuring sustained activation of PKA and subsequent effects on ACAM signaling.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylyl cyclase, leading to an increase in cAMP levels, which can enhance the activity of ACAM by cAMP-dependent protein kinase (PKA) activation and subsequent phosphorylation of proteins involved in ACAM-mediated signaling pathways. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases, preventing cAMP degradation; this results in elevated cAMP levels, which indirectly upregulates ACAM signaling through PKA activation. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is an activator of protein kinase C (PKC), which can phosphorylate target proteins that might interact with ACAM, leading to enhanced ACAM activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore, which elevates intracellular calcium levels, indirectly activating calcium-dependent kinases and phosphatases that can modulate ACAM signaling. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $97.00 $224.00 | 30 | |
8-Br-cAMP is a cAMP analog that activates PKA; PKA then phosphorylates target proteins that can interact with and activate ACAM. | ||||||
L-Arginine | 74-79-3 | sc-391657B sc-391657 sc-391657A sc-391657C sc-391657D | 5 g 25 g 100 g 500 g 1 kg | $20.00 $30.00 $60.00 $215.00 $345.00 | 2 | |
L-Arginine serves as a substrate for nitric oxide synthase, which can produce nitric oxide, a signaling molecule that could enhance ACAM activity through S-nitrosylation of regulatory proteins. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is a broad inhibitor of protein kinases and has been shown to affect multiple signaling pathways; it might increase ACAM activity by inhibiting kinases that normally phosphorylate inhibitory sites on proteins associated with ACAM signaling. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $94.00 $173.00 $255.00 $423.00 | 26 | |
Capsaicin is an agonist of the transient receptor potential vanilloid 1 (TRPV1) receptor; activation of TRPV1 can lead to an increase in intracellular calcium, which may promote ACAM signaling through calcium-dependent pathways. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram is an inhibitor of phosphodiesterase 4, leading to increased cAMP levels; this elevation might enhance ACAM activity via PKA signaling. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $56.00 $186.00 $296.00 $655.00 $2550.00 $3500.00 $10500.00 | 4 | |
NAD+ is a coenzyme involved in redox reactions; it can also serve as a substrate for ADP-ribosylation, which may indirectly modify proteins that regulate ACAM signaling. | ||||||