Abin-3 Inhibitors
Abin-3 inhibitors constitute a collection of compounds primarily characterized by their capacity to modulate the NF-κB signaling pathway, either directly or indirectly. Given Abin-3's association with this crucial signaling cascade involved in immune and inflammatory processes, these inhibitors can significantly influence Abin-3's function by regulating the upstream components of the pathway.
Compounds such as BAY 11-7082, Parthenolide, and IMD-0354 are exemplary of this category, demonstrating their influence by impeding various stages of the NF-κB activation process. For instance, BAY 11-7082 focuses on inhibiting IκBα phosphorylation, while Parthenolide acts by inhibiting IκBα degradation. MG-132, being a proteasome inhibitor, offers a more global approach by averting the degradation of multiple proteins, including IκBα, thus indirectly impacting NF-κB activation and the associated functions of Abin-3. Additionally, compounds like Curcumin and Resveratrol bring forth an integrative approach by affecting the NF-κB pathway through diverse mechanisms.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $61.00 $83.00 $349.00 | 155 | |
Irreversibly inhibits IκBα phosphorylation, thus preventing NF-κB activation and possibly influencing Abin-3 activity. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $79.00 $300.00 | 32 | |
Inhibits NF-κB activation by preventing IκBα degradation, which can indirectly affect Abin-3. | ||||||
IMD 0354 | 978-62-1 | sc-203084 | 5 mg | $199.00 | 3 | |
Inhibits IκB kinase, preventing the activation of NF-κB and potentially influencing Abin-3. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Disrupts NF-κB signaling by various means, which can influence Abin-3's functional role in the pathway. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
A proteasome inhibitor that prevents degradation of IκBα, thereby inhibiting NF-κB activation and possibly impacting Abin-3. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Interferes with NF-κB activation, which can indirectly affect the roles of Abin-3 in the pathway. | ||||||
Celastrol, Celastrus scandens | 34157-83-0 | sc-202534 | 10 mg | $155.00 | 6 | |
Inhibits NF-κB activation, thereby potentially influencing Abin-3's functional roles. | ||||||
QNZ | 545380-34-5 | sc-200675 | 1 mg | $115.00 | 12 | |
Blocks NF-κB activation by inhibiting TNFα-induced IκBα phosphorylation, which may indirectly impact Abin-3. | ||||||
NFκB Activation Inhibitor II, JSH-23 | 749886-87-1 | sc-222061 sc-222061C sc-222061A sc-222061B | 5 mg 10 mg 50 mg 100 mg | $210.00 $252.00 $1740.00 $1964.00 | 34 | |
Inhibits NF-κB nuclear translocation, potentially affecting downstream proteins like Abin-3. | ||||||
Caffeic acid phenethyl ester | 104594-70-9 | sc-200800 sc-200800A sc-200800B | 20 mg 100 mg 1 g | $70.00 $290.00 $600.00 | 19 | |
Inhibits NF-κB activation, potentially affecting the functionality of Abin-3 in the pathway. | ||||||