A730069N07Rik Activators
Chemical activators of DLC1 employ various molecular mechanisms to enhance its tumor suppressor function. Genistein, a tyrosine kinase inhibitor, can lead to the activation of DLC1 by inhibiting tyrosine kinases that act as negative regulators of DLC1's activity. This, in turn, allows DLC1 to exert its effects through its Rho-GAP domain. Similarly, resveratrol can activate DLC1 through the stimulation of AMP-activated protein kinase (AMPK), which has downstream effects, including the activation of DLC1. Epigallocatechin gallate (EGCG) contributes to the activation of DLC1 by inhibiting the PI3K/Akt pathway, which is known to phosphorylate and inhibit DLC1. By blocking this pathway, EGCG promotes DLC1 activation. Furthermore, curcumin activates DLC1 by inhibiting the NF-kB pathway, which otherwise suppresses the expression of tumor suppressor proteins including DLC1. Sulforaphane, by activating Nrf2, leads to the activation of antioxidant response elements that can trigger the activation of tumor suppressor proteins like DLC1.
In addition to the above mechanisms, quercetin can activate DLC1 by inhibiting Src family kinases, which may otherwise phosphorylate and inactivate DLC1. Silibinin contributes to DLC1 activation by inhibiting the STAT3 pathway, lifting the suppressive effects on DLC1. Indole-3-carbinol promotes DLC1 activation through the modulation of estrogen receptor signaling, which is connected to the regulation of DLC1. Caffeic acid phenethyl ester (CAPE) enhances DLC1's activity by blocking the activation of NF-kB, a regulator of tumor suppressor proteins. Capsaicin's role in DLC1 activation is associated with its modulation of calcium influx, which impacts calcium-dependent signaling pathways that regulate DLC1. Ellagic acid facilitates DLC1 activation by preventing the interaction between DLC1 and its negative regulators, thus stabilizing DLC1. Lastly, withaferin A induces DLC1 activation by inducing oxidative stress, which affects the signaling pathways that control the function of tumor suppressor proteins like DLC1.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein, a tyrosine kinase inhibitor, can lead to the activation of deleted in liver cancer 1 (DLC1) by inhibiting tyrosine kinases that negatively regulate DLC1's activity. This results in the enhancement of DLC1's tumor suppressor function through its Rho-GAP domain. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates AMP-activated protein kinase (AMPK) which in turn can activate DLC1. AMPK activation leads to various downstream effects that include the activation of tumor suppressor proteins such as DLC1. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG can activate DLC1 by inhibiting the PI3K/Akt pathway, which normally phosphorylates and inhibits DLC1. By blocking this inhibitory pathway, EGCG can promote the activation of DLC1. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin can activate DLC1 by inhibiting the NF-kB pathway, which is known to downregulate the expression of various tumor suppressor proteins. Inhibition of NF-kB can relieve its suppressive effect on DLC1, leading to its activation. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane activates nuclear factor erythroid 2–related factor 2 (Nrf2), which has been shown to activate antioxidant response elements (AREs) that are related to the expression and activation of tumor suppressor proteins, including DLC1. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin is known to inhibit Src family kinases, which can lead to the activation of DLC1 as these kinases may phosphorylate and inhibit DLC1. By inhibiting these kinases, quercetin indirectly activates DLC1. | ||||||
Silybin | 22888-70-6 | sc-202812 sc-202812A sc-202812B sc-202812C | 1 g 5 g 10 g 50 g | $54.00 $112.00 $202.00 $700.00 | 6 | |
Silibinin can activate DLC1 by inhibiting the STAT3 pathway, which when active can suppress the tumor suppressor functions of proteins like DLC1. By inhibiting STAT3, silibinin can promote the activation of DLC1. | ||||||
Indole-3-carbinol | 700-06-1 | sc-202662 sc-202662A sc-202662B sc-202662C sc-202662D | 1 g 5 g 100 g 250 g 1 kg | $38.00 $60.00 $143.00 $306.00 $1012.00 | 5 | |
Indole-3-carbinol activates DLC1 by modulating estrogen receptor signaling, which is implicated in the regulation of DLC1 activity. This chemical can thus indirectly promote DLC1 activation through hormone signaling pathways. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $94.00 $173.00 $255.00 $423.00 | 26 | |
Capsaicin can activate DLC1 by modulating calcium influx and subsequently affecting calcium-dependent signaling pathways that are known to regulate the activity of proteins like DLC1. | ||||||
Ellagic Acid, Dihydrate | 476-66-4 | sc-202598 sc-202598A sc-202598B sc-202598C | 500 mg 5 g 25 g 100 g | $57.00 $93.00 $240.00 $713.00 | 8 | |
Ellagic acid can activate DLC1 by inhibiting the interaction between DLC1 and its negative regulators, leading to the stabilization and activation of DLC1's tumor suppressor activity. | ||||||