9530077C05Rik Inhibitors
Chemical inhibitors of Microtubule associated tyrosine carboxypeptidase 2 (MTCAP2) function through the modulation of microtubule dynamics, which are essential for the protein's activity. Paclitaxel and Peloruside A achieve inhibition by stabilizing microtubules, thus preventing their disassembly and, consequently, inhibiting the dynamics that MTCAP2 relies upon. In a similar vein, Eribulin targets the growth phase of microtubule dynamics, leading to an inhibition of MTCAP2 by preventing the proper microtubule structure it requires to function. On the other end of the spectrum, Colchicine, Vinblastine, and Vincristine disrupt MTCAP2 activity by binding to tubulin and preventing its polymerization, thus inhibiting the formation of the microtubule structures that are integral to MTCAP2's function.
Certain chemical inhibitors operate by disrupting the assembly and polymerization of microtubules, which are pivotal for MTCAP2's role within the cell. Nocodazole, Podophyllotoxin, Griseofulvin, Thiabendazole, Albendazole, and Mebendazole all fall into this category. These chemicals bind to tubulin or interfere with its ability to form microtubules, which results in the disruption of microtubule networks critical for the functional capacity of MTCAP2. By inhibiting the formation of these essential cellular structures, these compounds directly impact the ability of MTCAP2 to carry out its associated processes within the cell. Each of these inhibitors, through their distinct interactions with tubulin or microtubules, ensures that the proper assembly or stability of microtubules required for MTCAP2 activity is compromised, leading to the functional inhibition of the protein.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Paclitaxel stabilizes microtubules and thereby inhibits their disassembly, leading to inhibition of microtubule dynamics. Microtubule associated tyrosine carboxypeptidase 2 (MTCAP2) requires dynamic microtubules for its function; stabilization of microtubules by paclitaxel can result in the functional inhibition of MTCAP2. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Colchicine binds to tubulin, one of the main constituents of microtubules, preventing its polymerization. As MTCAP2 associates with microtubules, the inhibition of microtubule polymerization by colchicine disrupts the cellular context necessary for MTCAP2 to exert its function. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole is a synthetic inhibitor of microtubule polymerization. By disrupting microtubule assembly, nocodazole can inhibit the activity of MTCAP2, which relies on intact microtubule structures to function properly. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $102.00 $235.00 $459.00 $1749.00 $2958.00 | 4 | |
Vinblastine binds to tubulin and inhibits microtubule formation. This action inhibits MTCAP2 by disrupting the microtubules that MTCAP2 is associated with, thereby inhibiting its function. | ||||||
Podophyllotoxin | 518-28-5 | sc-204853 | 100 mg | $84.00 | 1 | |
Podophyllotoxin inhibits tubulin polymerization and thus microtubule assembly. Since MTCAP2's function is related to microtubules, the inhibition of their assembly by podophyllotoxin leads to functional inhibition of MTCAP2. | ||||||
Eribulin | 253128-41-5 | sc-507547 | 5 mg | $865.00 | ||
Eribulin inhibits the growth phase of microtubule dynamics, which would inhibit MTCAP2 by preventing the proper microtubule structure it requires to function. | ||||||
Griseofulvin | 126-07-8 | sc-202171A sc-202171 sc-202171B | 5 mg 25 mg 100 mg | $85.00 $220.00 $598.00 | 4 | |
Griseofulvin disrupts microtubule function by binding to tubulin and inhibiting its polymerization. This inhibits MTCAP2 by affecting the microtubule structures that are essential for its activity. | ||||||
Thiabendazole | 148-79-8 | sc-204913 sc-204913A sc-204913B sc-204913C sc-204913D | 10 g 100 g 250 g 500 g 1 kg | $32.00 $84.00 $183.00 $312.00 $572.00 | 5 | |
Thiabendazole inhibits microtubule polymerization. The inhibition of microtubule formation by thiabendazole would result in the functional inhibition of MTCAP2. | ||||||
Albendazole | 54965-21-8 | sc-210771 | 100 mg | $213.00 | 1 | |
Albendazole disrupts microtubule polymerization. By inhibiting the formation of microtubules, albendazole can lead to functional inhibition of MTCAP2. | ||||||
Mebendazole | 31431-39-7 | sc-204798 sc-204798A | 5 g 25 g | $46.00 $89.00 | 2 | |
Mebendazole inhibits the formation of microtubules. This action can inhibit MTCAP2 function by disrupting the microtubule structures necessary for its activity | ||||||