6430531B16Rik Inhibitors
Chemical class Spef1l Inhibitors includes a diverse set of compounds that target various signaling pathways and cellular processes to indirectly influence the function of the SPEF1L protein. These inhibitors are not uniform in their action or specificity; rather, they act on a range of targets that are implicated in the regulation of flagellar motility and structure. The inhibitors function by modifying the activity of kinases, phosphatases, or other enzymes and proteins that play a role in cellular signaling pathways, such as PI3K/AKT, MAPK/ERK, and PKC. Additionally, some compounds affect cytoskeletal dynamics and energy production, which are fundamental for the proper assembly and function of the flagellum.
The inhibition of these pathways or processes by the listed chemicals can alter the phosphorylation state of proteins, the assembly of the cytoskeleton, or the generation and utilization of ATP, all of which are vital for sperm motility and flagellar integrity. The chemicals span various classes, including kinase inhibitors, ATPase inhibitors, and agents that affect the polymerization state of cytoskeletal components. The modulation of these pathways or processes by the various inhibitors can ultimately influence the structural and functional properties of sperm flagella, where SPEF1L is known to be important.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
A PI3K inhibitor that can impede the PI3K/AKT pathway, which is involved in many cellular processes, including motility and flagellar function. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
A MEK inhibitor that can disrupt the MAPK/ERK pathway, potentially affecting cellular functions that are crucial for flagellar assembly and maintenance. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
JNK inhibitor that can alter signaling pathways associated with cytoskeletal dynamics, which are important for sperm flagellum structure and function. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
A p38 MAPK inhibitor that can impact cytoskeletal regulation, potentially affecting the structural integrity of the flagellum. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
A ROCK inhibitor which can influence actin filament assembly and disassembly, processes that are critical for flagellar movement. | ||||||
(S)-(−)-Blebbistatin | 856925-71-8 | sc-204253 sc-204253A sc-204253B sc-204253C | 1 mg 5 mg 10 mg 25 mg | $72.00 $265.00 $495.00 $968.00 | ||
An inhibitor of non-muscle myosin II ATPase activity, which can affect intracellular transport and cytoskeletal dynamics, relevant for flagellum structure. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $91.00 $267.00 | 13 | |
A myosin light chain kinase inhibitor, which can affect the phosphorylation state of myosin light chains, crucial for proper flagellar function. | ||||||
Gö 6983 | 133053-19-7 | sc-203432 sc-203432A sc-203432B | 1 mg 5 mg 10 mg | $105.00 $299.00 $474.00 | 15 | |
A broad-spectrum PKC inhibitor that can modify the phosphorylation state of proteins associated with sperm motility and flagellar structure. | ||||||
Rotenone | 83-79-4 | sc-203242 sc-203242A | 1 g 5 g | $89.00 $259.00 | 41 | |
Inhibits mitochondrial Complex I, potentially affecting ATP production, which is necessary for flagellar beat and movement. | ||||||
2,3-Butanedione 2-Monoxime | 57-71-6 | sc-203774 sc-203774A sc-203774B sc-203774C | 25 g 100 g 250 g 500 g | $42.00 $78.00 $161.00 $286.00 | ||
Affects muscle contraction by inhibiting myosin ATPase, which can indirectly influence flagellar motility through energy modulation. | ||||||