6330416L07Rik Inhibitors
Chemical inhibitors of the protein encoded by 6330416L07Rik can exert their inhibitory effects through various mechanisms tied to the pathways the protein is involved in. PD98059, as a selective inhibitor of MEK, can prevent the activation of ERK, a kinase that is often necessary for the phosphorylation of numerous proteins. If the protein in question is regulated via the MEK/ERK pathway, PD98059 would inhibit its activity by impeding this crucial phosphorylation step. Similarly, SB203580 targets p38 MAP kinase, another molecule in the mitogen-activated protein kinase (MAPK) family, which is involved in cellular responses to stress and inflammation. By inhibiting p38 MAP kinase, SB203580 can disrupt the protein's activity if it is a downstream effector in this pathway.
The protein's activity can also be modulated by inhibitors that target phosphoinositide 3-kinases (PI3K), such as LY294002 and Wortmannin. By specifically inhibiting PI3K, these compounds can suppress the PI3K/Akt signaling pathway, which is critical for various cellular functions including metabolism, growth, and survival. If the protein encoded by 6330416L07Rik is an Akt substrate or is otherwise regulated by PI3K signaling, LY294002 and Wortmannin would result in inhibition of its activity. Further along the signaling cascade, Rapamycin inhibits the mTOR pathway, which could lead to inhibition of the protein if it is involved in processes affected by mTOR. Moreover, PP2, targeting Src family tyrosine kinases, can inhibit the protein's activity by preventing tyrosine phosphorylation that might be necessary for its function. Y-27632, an inhibitor of ROCK kinases, can impede the protein's involvement in cytoskeleton organization-related pathways by preventing downstream phosphorylation events. If the protein interacts with components of the FGFR pathway, PD173074 would inhibit it by blocking FGFR's tyrosine kinase activity. ZM-447439 could disrupt the protein's function if it plays a role in cell cycle regulation mediated by Aurora kinases. Lastly, SP600125, by inhibiting JNK, would affect the protein's activity if it is regulated through the JNK signaling pathway. Staurosporine, a broad-spectrum kinase inhibitor, can non-selectively inhibit various kinases; therefore, if the protein's function is contingent upon phosphorylation by any kinase, Staurosporine could serve as an inhibitor.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a selective and cell-permeable inhibitor of MAPK/ERK kinase (MEK), which blocks the activation of ERK. Since ERK is necessary for the phosphorylation of many proteins, inhibiting this kinase can prevent the phosphorylation and subsequent activation of 6330416L07Rik, assuming it is downstream of the MEK/ERK pathway. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a selective inhibitor of p38 MAP kinase. By inhibiting p38 MAP kinase, SB203580 can disrupt downstream signaling that includes the phosphorylation and activation of various substrates and regulators. If 6330416L07Rik functions downstream of p38 MAPK, its activity would be functionally inhibited as a consequence of p38 MAPK inhibition. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a specific inhibitor of phosphatidylinositol 3-kinase (PI3K). Inhibition of PI3K leads to the suppression of the Akt signaling pathway, which is involved in the regulation of various cellular processes. If 6330416L07Rik is an Akt substrate or is regulated by the PI3K/Akt pathway, its activity would be inhibited by LY294002. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is another potent and irreversible inhibitor of PI3K. Similar to LY294002, if 6330416L07Rik operates downstream of PI3K, Wortmannin would result in the inhibition of its function by preventing the activation of the PI3K/Akt pathway. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits the mammalian target of rapamycin (mTOR), a key regulator in cell growth and proliferation. If 6330416L07Rik is implicated in mTOR signaling or its function is influenced by mTOR activity, rapamycin would inhibit 6330416L07Rik by suppressing mTOR signaling. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
PP2 is a selective inhibitor of Src family tyrosine kinases. Src kinases can phosphorylate a wide range of substrates, potentially including 6330416L07Rik. If 6330416L07Rik is a substrate for Src family kinases or is functionally dependent on Src signaling, PP2 would inhibit the protein by blocking Src kinase activity. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 is an inhibitor of Rho-associated kinases (ROCK), which are involved in actin cytoskeleton organization. If 6330416L07Rik is involved in pathways regulated by ROCK, such as cell shape, motility, or adhesion, Y-27632 would inhibit 6330416L07Rik by preventing the phosphorylation and activation of downstream targets within the ROCK signaling pathway. | ||||||
PD173074 | 219580-11-7 | sc-202610 sc-202610A sc-202610B | 1 mg 5 mg 50 mg | $46.00 $140.00 $680.00 | 16 | |
PD173074 is a selective inhibitor of the fibroblast growth factor receptor (FGFR) tyrosine kinase. If 6330416L07Rik's activity is mediated through FGFR signaling, PD173074 would inhibit 6330416L07Rik by blocking the kinase activity of FGFR and thus the downstream signaling cascade. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $150.00 $349.00 | 15 | |
ZM-447439 is an Aurora kinase inhibitor. Aurora kinases play roles in the regulation of mitosis. If 6330416L07Rik is involved in mitotic processes regulated by Aurora kinases, ZM-447439 would inhibit the protein by blocking the activity of these kinases, thereby disrupting the cell cycle events that 6330416L07Rik may regulate. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK), which is implicated in a variety of cellular processes, including apoptosis and gene expression. If 6330416L07Rik is a component of the JNK signaling pathway, or if its activity is regulated by JNK, SP600125 would inhibit 6330416L07Rik by preventing the activation of JNK. | ||||||