5033411D12Rik Inhibitors
Chemical inhibitors of 5033411D12Rik encompass a variety of compounds that impede different kinases and signaling pathways, which can regulate the activity of this protein. Wortmannin and LY294002, both phosphoinositide 3-kinases (PI3K) inhibitors, can disrupt the PI3K-AKT pathway, leading to decreased phosphorylation of AKT and its downstream targets, which may include 5033411D12Rik. Similarly, Rapamycin, by selectively inhibiting the mammalian target of rapamycin (mTOR), can suppress downstream signaling that is critical for various cellular functions, potentially affecting the regulation of 5033411D12Rik. Staurosporine, a broad-spectrum kinase inhibitor, can inhibit a wide array of protein kinases, potentially diminishing the phosphorylation state of proteins that are involved in the regulation of 5033411D12Rik, thereby decreasing its activity.
Furthermore, PD98059 and U0126, both specific MEK inhibitors, can inhibit the MEK-ERK pathway, which may reduce the phosphorylation and regulation of substrates involved in the function of 5033411D12Rik. Inhibition of the p38 MAP kinase by SB203580 and the JNK pathway by SP600125 can also lead to reduced signaling to proteins that control the activity of 5033411D12Rik. PP2, a Src family tyrosine kinases inhibitor, can disrupt kinases that phosphorylate substrates governing various signaling pathways, which can affect 5033411D12Rik. Y-27632 targets Rho-associated protein kinase (ROCK) and can influence actin cytoskeleton dynamics, potentially affecting the function of 5033411D12Rik if it is associated with these cellular processes. Lastly, PD173074, an inhibitor of the FGFR tyrosine kinase, can obstruct FGFR-mediated signaling, which can alter the activity of proteins regulated by this pathway, including 5033411D12Rik.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a specific inhibitor of phosphoinositide 3-kinases (PI3K). By inhibiting PI3K, it can reduce the phosphorylation of AKT, a kinase downstream in the PI3K pathway. Since 5033411D12Rik is a protein that might be regulated by AKT through phosphorylation, inhibition of PI3K by Wortmannin could lead to reduced activity of 5033411D12Rik. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin selectively inhibits the mammalian target of rapamycin (mTOR), a key regulatory kinase. Through the inhibition of mTOR, Rapamycin can suppress downstream signaling pathways that are crucial for protein translation and other cellular processes. This suppression could reduce the functional activity of 5033411D12Rik by inhibiting its regulatory mechanisms. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is another PI3K inhibitor, which in a similar manner to Wortmannin, can prevent the PI3K-AKT signaling pathway. By blocking this pathway, LY294002 could inhibit the phosphorylation and activation of downstream targets of AKT, leading to a decrease in 5033411D12Rik activity if it is regulated by those downstream targets. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent inhibitor of a wide range of protein kinases. By blocking kinase activity, Staurosporine can inhibit the phosphorylation of proteins that may be essential for the activity of 5033411D12Rik. This broad inhibition of kinases could result in decreased functionality of 5033411D12Rik if it relies on phosphorylation for activity. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a selective inhibitor of mitogen-activated protein kinase kinase (MEK), which is upstream of extracellular signal-regulated kinases (ERK1/2). Inhibition of MEK by PD98059 could decrease ERK1/2 activity, potentially reducing the phosphorylation of substrates involved in the regulation of 5033411D12Rik, thereby inhibiting its activity. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is also a specific MEK inhibitor, similar to PD98059, and can inhibit the activation of the ERK pathway. By inhibiting MEK, U0126 can reduce the activity of ERK1/2 and their downstream signaling, which could lead to functional inhibition of 5033411D12Rik if it is regulated by the ERK pathway. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a selective inhibitor of p38 MAP kinase. The inhibition of p38 MAP kinase by SB203580 could lead to the suppression of downstream signaling pathways that may regulate the function of 5033411D12Rik, resulting in the inhibition of the protein's activity. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK). By inhibiting JNK, SP600125 could interfere with the JNK signaling pathway, leading to a decrease in the phosphorylation of JNK substrates, which may include regulatory proteins of 5033411D12Rik, thus inhibiting the functional activity of 5033411D12Rik. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
PP2 is an inhibitor of Src family tyrosine kinases. Src kinases can phosphorylate a variety of substrates that are involved in different signaling pathways. Inhibition of Src kinases by PP2 could disrupt signaling pathways that regulate the activity of 5033411D12Rik, thereby leading to its functional inhibition. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 is an inhibitor of Rho-associated protein kinase (ROCK). By inhibiting ROCK, Y-27632 could affect the actin cytoskeleton dynamics and cell motility. Since the Rho/ROCK pathway can regulate a wide range of cellular processes, inhibition by Y-27632 could lead to functional inhibition of 5033411D12Rik if the protein's activity is linked to these processes. | ||||||