4930511J11Rik Activators
4930511J11Rik Activators are a diverse set of chemical compounds that indirectly enhance the functional activity of 4930511J11Rik by modulating various cellular signaling pathways. The elevation of intracellular cAMP by Forskolin or inhibition of phosphodiesterases by IBMX leads to PKA activation. PKA, in turn, can phosphorylate downstream targets, thereby enhancing the signaling cascades that 4930511J11Rik is a part of. The same mechanism can be attributed to A23187, which, by increasing intracellular calcium, would activate calcium-dependent kinases, potentially amplifying 4930511J11Rik's activity. The classification of compounds known as 4930511J11Rik Activators refers to a group of chemicals that can enhance the expression of the 4930511J11Rik gene. The initial step in identifying these activators involves a process known as high-throughput screening (HTS), which allows for the rapid evaluation of numerous compounds and their effects on gene expression. This screening utilizes a reporter gene assay, in which a detectable reporter, such as a luminescent or fluorescent protein, is placed under the regulatory control of the 4930511J11Rik gene's promoter.
The intensity of this signal serves as a quantitative indicator of the compound's ability to activate the gene. Compounds that elicit a substantial elevation in the reporter signal are identified as primary hits and are selected for further analysis. This selective process enables researchers to concentrate on compounds that specifically target and activate the 4930511J11Rik gene, facilitating a more focused investigation into their gene regulatory properties. Following the high-throughput screening, those compounds classified as potential 4930511J11Rik Activators undergo further validation to confirm their gene-activating capabilities.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
Sphingosine-1-phosphate engages with its G protein-coupled receptors, leading to downstream signaling cascades that can upregulate the activity of 4930511J11Rik by modulating cellular processes such as migration and angiogenesis where 4930511J11Rik could be implicated. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases, which increases cAMP levels, similarly to Forskolin, this elevation in cAMP can potentiate PKA activity which in turn may enhance the signaling pathways involving 4930511J11Rik. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Phorbol 12-myristate 13-acetate (PMA) activates protein kinase C (PKC), which can phosphorylate substrates that are part of the signaling pathways in which 4930511J11Rik operates, resulting in the enhanced functional activity of 4930511J11Rik. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
As a kinase inhibitor, Epigallocatechin gallate can modulate various signaling cascades, potentially reducing signal noise and allowing clearer signaling through pathways in which 4930511J11Rik functions, indirectly enhancing its activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that can modulate the PI3K/AKT pathway. By inhibiting this pathway, LY294002 may shift cellular signaling dynamics in a way that indirectly upregulates 4930511J11Rik activity. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is another PI3K inhibitor that works similarly to LY294002 in shifting cellular signaling dynamics to potentially enhance the function of 4930511J11Rik indirectly. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAPK inhibitor that can modify the signaling equilibrium, potentially enhancing signaling processes that are positively influenced by 4930511J11Rik activity. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is a calcium ionophore that increases intracellular calcium levels, activating calcium-dependent signaling pathways that may enhance the functional activity of 4930511J11Rik by promoting processes it is involved in. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is a tyrosine kinase inhibitor. By inhibiting competitive signaling pathways, it may lead to enhanced functional signaling of pathways where 4930511J11Rik is active. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine, a broad-spectrum protein kinase inhibitor, might lead to selective activation of pathways that involve 4930511J11Rik by reducing the inhibitory regulation on those pathways. | ||||||