2810422J05Rik Inhibitors
Chemical inhibitors of the protein 2810422J05Rik can interfere with its function by targeting various kinases and signaling pathways that are essential for its activity within cells. Staurosporine, for instance, is a broad-spectrum kinase inhibitor which can hinder the activity of kinases responsible for the phosphorylation of 2810422J05Rik, thus preventing its activation. Similarly, both wortmannin and LY294002 are inhibitors of phosphoinositide 3-kinases (PI3K), which play a critical role in the PI3K/AKT signaling pathway. The inhibition of PI3K by these chemicals can prevent the downstream activation of AKT, which is necessary for the functional operation of 2810422J05Rik. Additionally, PD98059 and U0126 target the MAPK/ERK pathway by inhibiting MEK1 and MEK2, resulting in decreased activation of ERK, which, in turn, can limit the signaling processes involving 2810422J05Rik.
Further affecting the protein, SB203580 and SB202190 are selective inhibitors of p38 MAP kinase, and their action disrupts the p38 MAPK signaling pathway which is also implicated in the regulation of 2810422J05Rik. Rapamycin, by specifically inhibiting mTOR, affects the PI3K/AKT/mTOR pathway and consequently the activation of downstream targets that play a role in the functional activity of 2810422J05Rik. Additionally, the Src family kinases, which are the target of the inhibitor PP2, are part of the cellular signaling that regulates 2810422J05Rik activity. Inhibition by PP2 can thus suppress the pathway's activity. SP600125, which inhibits c-Jun N-terminal kinase (JNK), can block the JNK signaling pathway required for the operation of 2810422J05Rik within certain contexts. Lastly, GF109203X and Bisindolylmaleimide I (Go6976) inhibit protein kinase C (PKC), which is involved in numerous signaling pathways, and this inhibition can lead to the suppression of PKC-dependent signaling pathways that involve 2810422J05Rik.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases. For 2810422J05Rik, given its role in specific signaling pathways, staurosporine can inhibit the protein by targeting the kinases that phosphorylate the protein, thereby preventing its activation and subsequent signaling. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a specific inhibitor of phosphoinositide 3-kinases (PI3K). Given that 2810422J05Rik is involved in PI3K/AKT signaling, wortmannin's inhibition of PI3K can prevent the activation of AKT, a downstream target in the pathway, which would be necessary for the full functional activity of 2810422J05Rik. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is another specific inhibitor of PI3K, functioning similarly to wortmannin. By inhibiting PI3K, LY294002 can prevent the downstream signaling that would involve 2810422J05Rik, thereby functionally inhibiting the protein. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 inhibits MEK, which is involved in the MAPK/ERK pathway. By inhibiting MEK, PD98059 can prevent the activation of ERK, which is necessary for the downstream signaling that includes the functional activity of 2810422J05Rik. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is a selective inhibitor of both MEK1 and MEK2. As these kinases are upstream regulators of the MAPK/ERK pathway, their inhibition by U0126 would result in reduced ERK activation, thereby inhibiting the signaling pathways in which 2810422J05Rik is involved. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 selectively inhibits p38 MAP kinase. Inhibition of p38 MAP kinase by SB203580 would disrupt the p38 MAPK signaling pathway, which is part of the signaling networks involving 2810422J05Rik, leading to its functional inhibition. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin specifically inhibits mTOR (mechanistic target of rapamycin), which is a central component of the PI3K/AKT/mTOR pathway. Since 2810422J05Rik is involved in this pathway, the inhibition of mTOR by rapamycin would lead to decreased activation of downstream targets that are essential for the functional activity of 2810422J05Rik. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
PP2 is an inhibitor of Src family kinases. These kinases are involved in multiple signaling pathways, including those that regulate the activity of 2810422J05Rik. By inhibiting Src kinases, PP2 can prevent the phosphorylation and activation of downstream molecules that would be involved in the functional activity of 2810422J05Rik. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK). By inhibiting JNK, SP600125 can block the JNK signaling pathway, which may be required for the functional activity of 2810422J05Rik within certain cellular contexts. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
GF109203X is a potent inhibitor of protein kinase C (PKC). Since PKC is involved in a wide range of signaling pathways, the inhibition of PKC by GF109203X can lead to the suppression of pathways that are necessary for the functional activity of 2810422J05Rik. | ||||||