2610024E20Rik Inhibitors
Chemical inhibitors of the protein 2610024E20Rik can affect its function through various biochemical pathways by targeting specific enzymes and kinases involved in cellular signaling. Alsterpaullone operates by inhibiting cyclin-dependent kinases, which are key for the regulation of the cell cycle. When these kinases are inhibited, the subsequent phosphorylation and activation of 2610024E20Rik can be prevented, assuming that its activity is contingent upon CDK-mediated phosphorylation. Similarly, Wortmannin and LY294002 both act as inhibitors of phosphoinositide 3-kinases (PI3K). The inhibition of PI3K leads to a decrease in Akt-mediated signaling, affecting the activation state of 2610024E20Rik if it is indeed a downstream effector in this pathway. Rapamycin exerts its effect by binding to FKBP12 and subsequently inhibiting mTORC1, a central player in the mTOR signaling pathway, which influences protein synthesis and cell growth. This inhibition can affect the activity of 2610024E20Rik if it falls under the regulatory umbrella of mTORC1 signaling.
Staurosporine broadly targets protein kinases, disrupting multiple kinase-dependent signaling pathways, which can alter the functional state of 2610024E20Rik, particularly if its activation requires phosphorylation or protein interactions facilitated by these kinases. PD98059 and U0126 are both selective inhibitors of MEK, which acts upstream of ERK in the MAPK/ERK pathway. By inhibiting MEK, these chemicals prevent the activation of ERK, which can inhibit the phosphorylation and subsequent activation of 2610024E20Rik if it is an ERK substrate. In a similar vein, SB203580 selectively inhibits p38 MAP kinase, potentially preventing the activation of 2610024E20Rik through the p38 MAPK pathway. SP600125 targets c-Jun N-terminal kinase (JNK), and by inhibiting JNK, the JNK signaling pathway's activation of 2610024E20Rik can be obstructed if JNK-mediated phosphorylation is necessary for its activity. Lestaurtinib, a tyrosine kinase inhibitor, can inhibit JAK2, disrupting JAK/STAT signaling pathways, which may affect the functional state of 2610024E20Rik if it is a component of this pathway. Finally, Dasatinib and Sunitinib are inhibitors of Src family kinases and receptor tyrosine kinases, respectively, and their inhibition can impair the signaling pathways that rely on these kinases, potentially leading to the functional inhibition of 2610024E20Rik if it depends on these kinase-mediated activation processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Alsterpaullone | 237430-03-4 | sc-202453 sc-202453A | 1 mg 5 mg | $67.00 $306.00 | 2 | |
Alsterpaullone inhibits cyclin-dependent kinases (CDKs) which are crucial for cell cycle regulation. Inhibition of CDKs can lead to the functional inhibition of 2610024E20Rik by preventing its phosphorylation and activation if 2610024E20Rik requires CDK-mediated phosphorylation for its activity. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin inhibits phosphoinositide 3-kinases (PI3K), which are part of the PI3K/Akt signaling pathway. Inhibition of this pathway can lead to a decrease in Akt-mediated signaling, which can functionally inhibit 2610024E20Rik by preventing its activation by Akt if it is a downstream effector. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin binds to FKBP12 and inhibits mTORC1, a central component of the mTOR signaling pathway, which is involved in protein synthesis and cell growth. This inhibition can decrease the activity of downstream targets, potentially including 2610024E20Rik, if it is regulated by mTORC1 signaling. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases. By inhibiting multiple kinases, it can disrupt kinase-dependent signaling pathways that are necessary for the functional activity of 2610024E20Rik, such as its phosphorylation state or interaction with other proteins. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a chemical inhibitor of PI3K. By inhibiting PI3K, LY294002 can reduce Akt signaling. This reduction can lead to the functional inhibition of 2610024E20Rik by preventing any necessary PI3K/Akt-mediated activation processes. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a selective inhibitor of MEK, which works upstream of ERK in the MAPK/ERK pathway. By inhibiting MEK, PD98059 can prevent the activation of ERK and thereby inhibit the phosphorylation and activation of 2610024E20Rik if it is an ERK substrate. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 selectively inhibits p38 MAP kinase. Inhibition of p38 MAP kinase can lead to the functional inhibition of 2610024E20Rik by preventing its activation through the p38 MAPK pathway if 2610024E20Rik is a downstream target. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $65.00 $267.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK). By inhibiting JNK, SP600125 can prevent the JNK signaling pathway from activating 2610024E20Rik if the protein's activity is regulated by JNK-mediated phosphorylation. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is another MEK inhibitor that prevents the activation of ERK. By inhibiting MEK, U0126 can disrupt the MAPK/ERK signaling pathway and functionally inhibit 2610024E20Rik by preventing its ERK-dependent activation. | ||||||
Lestaurtinib | 111358-88-4 | sc-218657 sc-218657A sc-218657B | 1 mg 5 mg 10 mg | $270.00 $320.00 $600.00 | 3 | |
Lestaurtinib is a tyrosine kinase inhibitor that can inhibit JAK2, among other kinases. Inhibition of JAK2 can disrupt signaling pathways that rely on JAK/STAT signaling, functionally inhibiting 2610024E20Rik if it is a part of this pathway. | ||||||