1700020A23Rik Inhibitors
Chemical inhibitors of 1700020A23Rik employ a range of mechanisms to hinder its activity, each targeting specific signaling pathways and enzyme functions. Staurosporine, a potent protein kinase inhibitor, disrupts cellular signaling by inhibiting the kinase activities essential for phosphorylation, a modification vital for the activation of many proteins including 1700020A23Rik. Similarly, Wortmannin and LY294002, both PI3K inhibitors, obstruct the PI3K/Akt pathway, which is crucial for a variety of cellular functions. By preventing the phosphorylation of downstream targets within this pathway, these inhibitors can suppress the functional activity of 1700020A23Rik. This is achieved by blocking the transduction of signals necessary for its activation, thereby leading to a state of functional inhibition.
Further, Bisindolylmaleimide I targets Protein Kinase C (PKC), preventing its activity which may be integral for the functioning of 1700020A23Rik. PD98059 and U0126 specifically inhibit MEK1 and MEK1/2, respectively, which are upstream regulators of the ERK pathway. This inhibition results in the suppression of the ERK pathway, which could be necessary for the functional activity of 1700020A23Rik. SB203580's selective inhibition of p38 MAP kinase also leads to a similar outcome, disrupting signaling pathways that may involve 1700020A23Rik. Rapamycin, as an mTOR inhibitor, disrupts mTOR signaling pathways, which could be essential for 1700020A23Rik's activation and function. SP600125, by inhibiting c-Jun N-terminal kinase (JNK), interrupts signaling processes that could involve 1700020A23Rik, affecting its functional state. Lastly, Dasatinib and PP2, both Src family kinase inhibitors, obstruct kinases which may be required for 1700020A23Rik's phosphorylation and activation, resulting in its functional inhibition. ZM-447439's inhibition of Aurora kinases further exemplifies the targeted approach to control the activity of 1700020A23Rik, particularly in processes related to cell cycle and mitosis. Each chemical inhibitor achieves the functional inhibition of 1700020A23Rik through a specific blockade of the necessary kinases and signaling pathways involved in its regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine inhibits a wide range of protein kinases. By blocking the activity of kinases which are crucial for the phosphorylation state and activation of 1700020A23Rik, staurosporine functionally inhibits 1700020A23Rik's role in the signaling pathways it is involved in. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is an inhibitor of PI3K. By inhibiting PI3K, it disrupts PI3K/Akt pathway signaling, which is essential for numerous cellular processes including those that may involve 1700020A23Rik. This can lead to the functional inhibition of 1700020A23Rik by hindering related pathway activities. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002, like Wortmannin, is a PI3K inhibitor that blocks the PI3K/Akt pathway. It prevents the phosphorylation and activation of proteins downstream of PI3K, potentially leading to the functional inhibition of 1700020A23Rik through disruption of its associated signaling pathways. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
Bisindolylmaleimide I is an inhibitor of Protein Kinase C (PKC). It prevents PKC's activity, which could be necessary for the activation or function of 1700020A23Rik, leading to its functional inhibition by disabling essential signaling mechanisms. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 selectively inhibits MEK1, which is involved in the MAPK/ERK pathway. By inhibiting MEK1, PD98059 suppresses the ERK pathway that may be necessary for the functional activity of 1700020A23Rik, resulting in its inhibition. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is an inhibitor of both MEK1 and MEK2, which are upstream of ERK in the MAPK pathway. By inhibiting these kinases, U0126 can functionally inhibit 1700020A23Rik by preventing the activation of the MAPK pathway that it is part of. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a selective inhibitor of p38 MAP kinase. By inhibiting p38 MAP kinase, it could block the signaling pathways that involve 1700020A23Rik, leading to the functional inhibition of the protein through disruption of its signaling mechanisms. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an mTOR inhibitor. By inhibiting mTOR, it disrupts the mTOR signaling pathway, which can be crucial for the activation and function of 1700020A23Rik, leading to its functional inhibition. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK). Inhibition of JNK can lead to the functional inhibition of 1700020A23Rik if it is involved in JNK-mediated signaling processes, by disrupting the phosphorylation and activation of proteins within these pathways. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $47.00 $145.00 | 51 | |
Dasatinib is a Src family kinase inhibitor, and by inhibiting these kinases, it could interfere with signaling pathways that involve 1700020A23Rik, leading to functional inhibition of the protein by preventing necessary phosphorylation events. | ||||||