1700016J18Rik Inhibitors
Chemical inhibitors of 1700016J18Rik employ various mechanisms to impede the functional activity of this protein. Staurosporine is a potent inhibitor that non-selectively targets a wide range of protein kinases, which can lead to the suppression of kinase-dependent pathways integral to the activity of 1700016J18Rik. Similarly, Bisindolylmaleimide I focuses on protein kinase C (PKC), whose inhibition can disrupt downstream signaling processes essential for 1700016J18Rik's function. The chemical LY294002 targets PI3K, leading to the disruption of the PI3K/AKT signaling cascade, which is known to play a critical role in the functional activity of 1700016J18Rik. Wortmannin operates in a similar fashion, serving as another potent PI3K inhibitor, further interrupting pathways that are crucial for the proper activity of 1700016J18Rik.
Other chemical inhibitors like Rapamycin, U0126, and PD98059 focus on different targets within the cellular signaling networks. Rapamycin forms a complex with FKBP12, thereby inhibiting mTOR pathway which can be essential for the function of 1700016J18Rik. U0126 and PD98059 are selective inhibitors of MEK1/2 and prevent the activation of ERK1/2 within the MAPK pathway. By impeding this pathway, they limit the signaling that could be necessary for the function of 1700016J18Rik. SB203580 and SP600125 are specific to the MAPK pathway, targeting p38 MAP kinase and JNK respectively, and their inhibition is likely to reduce signaling that 1700016J18Rik relies on. Dasatinib and PP2, both kinase inhibitors, target the Src family of tyrosine kinases, whose activity is paramount for the signaling processes 1700016J18Rik may utilize. Lastly, ZM-447439's inhibition of Aurora kinases leads to the suppression of cell cycle progression-related signaling pathways that 1700016J18Rik might be involved in, thereby disrupting its function. Each inhibitor, through its unique mechanism, can suppress the functional activity of 1700016J18Rik by targeting specific molecules and pathways within the cell.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent, broad-spectrum inhibitor of protein kinases. Its inhibition of multiple kinases can lead to a downregulation of kinase-dependent signaling pathways, which, considering 1700016J18Rik’s activities, would result in the functional inhibition of 1700016J18Rik. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is an inhibitor of PI3K. By inhibiting PI3K, LY294002 can disrupt PI3K/AKT signaling, a pathway that can be essential for the functional activity of 1700016J18Rik, leading to its functional inhibition. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR by forming a complex with FKBP12, which can suppress downstream signaling required for the functional activity of 1700016J18Rik, thus leading to its inhibition. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 specifically inhibits p38 MAP kinase. Inhibition of p38 MAPK could suppress downstream signaling that 1700016J18Rik may rely on for its function, resulting in the inhibition of 1700016J18Rik. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is a selective inhibitor of MEK1/2, which are upstream of ERK in the MAPK pathway. Inhibition of MEK and subsequent reduction in ERK activity can inhibit signaling pathways that 1700016J18Rik relies on for its function, thereby inhibiting 1700016J18Rik. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
PP2 is an inhibitor of Src family tyrosine kinases. By inhibiting Src kinase activity, PP2 can disrupt signaling that may be essential for the functional activity of 1700016J18Rik, leading to its inhibition. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $150.00 $349.00 | 15 | |
ZM-447439 is an Aurora kinase inhibitor. By inhibiting Aurora kinases, it can inhibit cell cycle progression-related signaling pathways that 1700016J18Rik may utilize for its function, resulting in the inhibition of 1700016J18Rik. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
Bisindolylmaleimide I is a specific inhibitor of protein kinase C (PKC). Inhibiting PKC can disrupt downstream signaling pathways that 1700016J18Rik may depend on for its function, leading to the inhibition of 1700016J18Rik. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of JNK, part of the MAPK family. It can inhibit signaling pathways that are crucial for the functional activity of 1700016J18Rik, thus inhibiting the protein. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $47.00 $145.00 | 51 | |
Dasatinib is a broad-spectrum tyrosine kinase inhibitor with activity against Src family kinases. By inhibiting these kinases, Dasatinib can disrupt signaling required for 1700016J18Rik function, leading to its inhibition. | ||||||