1700016H13Rik Activators
RAI1 Activators comprise a distinct set of chemical compounds that indirectly enhance the functional activity of RAI1 through various signaling pathways, emphasizing the protein's role in neuronal development and plasticity. Compounds such as Forskolin and Rolipram elevate intracellular cAMP levels, thereby promoting CREB phosphorylation and gene expression patterns that are synergistic with RAI1's function, especially in synaptic transmission. Lithium chloride and SB-216763, through inhibition of GSK-3, stabilize proteins and transcription factors that work in concert with RAI1's involvement in neurodevelopment. Similarly, K252a and Dihydroxyphenylglycine impact neurotrophin and glutamatergic signaling, respectively, leading to potential enhancements in RAI1's regulatory role in neuronal growth and circadian rhythms.
RAI1 Activators are a collection of chemical compounds that indirectly amplify the activity of RAI1 by manipulating a variety of signaling pathways intrinsic to neurodevelopment and synaptic function. Forskolin and Rolipram, by augmenting intracellular cAMP levels, facilitate the phosphorylation of CREB, a transcription factor that operates in tandem with RAI1 to regulate gene expression pertinent to synaptic plasticity. This enhancement of RAI1 is further supported by Lithium chloride and SB-216763, which through inhibition of GSK-3, promote the stability and activity of proteins and transcription factors that collaborate with RAI1, thus influencing neurodevelopmental processes. The positive allosteric modulation of mGluR4 by VU0361737 and the activation of mGluR1 and mGluR5 by Dihydroxyphenylglycine modulate the glutamatergic transmission, a pathway critical for synaptic plasticity and circadian rhythm regulation, both of which are domains of RAI1's activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram inhibits phosphodiesterase 4, preventing cAMP degradation, thereby sustaining CREB activation and supporting RAI1 activity in neuronal signaling pathways. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride inhibits glycogen synthase kinase 3 (GSK-3), which can enhance RAI1 activity by stabilizing proteins and transcription factors that work cooperatively with RAI1 in neuronal development and plasticity. | ||||||
BMS-708163 | 1146699-66-2 | sc-364444 sc-364444A | 10 mg 50 mg | $480.00 $1455.00 | 1 | |
VU0361737 is a positive allosteric modulator of the metabotropic glutamate receptor 4 (mGluR4), potentially enhancing RAI1 activity indirectly by modulating glutamatergic transmission and synaptic plasticity where RAI1 is implicated. | ||||||
K-252a | 99533-80-9 | sc-200517 sc-200517B sc-200517A | 100 µg 500 µg 1 mg | $129.00 $214.00 $498.00 | 19 | |
K252a is a kinase inhibitor, notably of neurotrophin receptors, which could lead to increased RAI1 activity by altering neurotrophic signaling pathways that are known to interact with RAI1 function in neuronal growth and differentiation. | ||||||
(S)-3,5-DHPG | 162870-29-3 | sc-204256 sc-204256A | 5 mg 10 mg | $210.00 $353.00 | 2 | |
Dihydroxyphenylglycine is an agonist of mGluR1 and mGluR5, which can indirectly enhance RAI1 function by modulating glutamatergic neurotransmission, influencing neuronal development and circadian rhythm regulation involving RAI1. | ||||||
Tianeptine | 66981-73-5 | sc-213044 sc-213044A | 10 mg 50 mg | $250.00 $422.00 | ||
Tianeptine modulates glutamatergic transmission, potentially enhancing RAI1 activity by affecting synaptic plasticity and neurogenesis, processes in which RAI1 is a critical player. | ||||||
SB-216763 | 280744-09-4 | sc-200646 sc-200646A | 1 mg 5 mg | $71.00 $202.00 | 18 | |
SB-216763 is a GSK-3 inhibitor which may lead to the enhancement of RAI1 function by stabilizing associated proteins and transcription factors involved in synaptic plasticity and neuronal development in conjunction with RAI1. | ||||||
Picrotoxin | 124-87-8 | sc-202765 sc-202765A sc-202765B | 1 g 5 g 25 g | $67.00 $286.00 $1326.00 | 11 | |
Picrotoxin is a GABA receptor antagonist that can enhance neuronal excitability, potentially increasing RAI1 activity by influencing neurological pathways where GABAergic inhibition would otherwise decrease RAI1 function. | ||||||
6-Cyano-7-nitroquinoxaline-2,3-dione | 115066-14-3 | sc-505104 | 10 mg | $208.00 | 2 | |
CNQX is an AMPA/kainate receptor antagonist, which could lead to enhanced RAI1 function by modulating excitatory neurotransmission and synaptic plasticity in neuronal circuits that are influenced by RAI1. | ||||||