1700013G24Rik Inhibitors
Chemical inhibitors of the protein 1700013G24Rik act by interrupting various signaling pathways within cells that are essential for its function. PD98059 and U0126 are specific to the MEK1/2 enzymes, which are upstream of the ERK pathway. By inhibiting these enzymes, they prevent the phosphorylation and subsequent activation of ERK kinases, which are crucial for forwarding the signals that would normally involve the protein 1700013G24Rik. Similarly, SB203580 targets the p38 MAPK, another key player in the MAPK signaling pathways, and its inhibition can disrupt the protein's role in stress response mechanisms. SP600125 takes a different approach by inhibiting JNK, which is also part of the MAPK family, leading to a decrease in 1700013G24Rik's functional activity due to impaired signal transduction.
Further down the signaling cascade, LY294002 and Wortmannin exert their effects by targeting PI3K, an upstream regulator of the AKT pathway, which intersects with various signaling routes involving 1700013G24Rik. By inhibiting PI3K, these chemicals reduce AKT activation, a kinase that plays a pivotal role in the regulation of cell survival, proliferation, and growth, thereby indirectly influencing the function of 1700013G24Rik. Rapamycin, PP242, and Torin 1 focus on inhibiting the mTOR pathway, a central conduit for regulating cell growth and metabolism, which is often linked with the protein 1700013G24Rik's function. Rapamycin specifically inhibits the mTORC1 complex, while PP242 and Torin 1 inhibit both mTORC1 and mTORC2, leading to broader suppression of mTOR signaling. Triciribine directly inhibits AKT, preventing its activation and affecting downstream proteins including 1700013G24Rik. Lastly, ZSTK474 and PF-04691502, by specifically targeting PI3K and dual inhibiting PI3K/mTOR respectively, lead to the inhibition of the PI3K/AKT/mTOR pathway, which is integral to the proper functioning of the protein 1700013G24Rik.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a selective and potent inhibitor of MEK, which phosphorylates and activates ERK kinases. Since 1700013G24Rik is known to be involved in the MAPK/ERK pathway, PD98059's inhibition of MEK can lead to decreased ERK activity and consequently inhibit the downstream functions of 1700013G24Rik. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 functions as an inhibitor of MEK1/2, impairing the activation of the ERK pathway. With 1700013G24Rik operating within this pathway, U0126 can inhibit the protein's function by preventing the necessary phosphorylation events that would typically be mediated by ERK, which is downstream of MEK. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a well-known p38 MAPK inhibitor. By inhibiting p38 MAPK, SB203580 can disrupt the signaling cascade that includes 1700013G24Rik, thereby functionally inhibiting the protein's ability to fulfill its role in response to stress-activated stimuli. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 inhibits JNK, which is part of the MAPK signaling pathways. As JNK is involved in regulatory processes that potentially include 1700013G24Rik, inhibition by SP600125 can lead to a decrease in the functional activity of 1700013G24Rik due to impaired signal transduction. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is an inhibitor of PI3K, which is upstream of many signaling pathways including the AKT pathway. Given that 1700013G24Rik is part of the cellular signaling network, inhibition of PI3K by LY294002 can reduce AKT activation, indirectly inhibiting 1700013G24Rik's function in these pathways. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is another potent inhibitor of PI3K. It can inhibit 1700013G24Rik by preventing PI3K-dependent AKT activation, which is crucial for the function of several proteins involved in signaling pathways, including 1700013G24Rik. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin selectively inhibits mTORC1, which is a key regulator of cell growth and metabolism. Since 1700013G24Rik is associated with signaling pathways regulated by mTOR, rapamycin's inhibition of mTORC1 can lead to a functional inhibition of 1700013G24Rik. | ||||||
PP242 | 1092351-67-1 | sc-301606A sc-301606 | 1 mg 5 mg | $56.00 $169.00 | 8 | |
PP242 is a selective inhibitor of both mTORC1 and mTORC2 complexes. Inhibition of these complexes can disrupt signaling pathways that include 1700013G24Rik, leading to its functional inhibition due to impaired mTOR signaling. | ||||||
Torin 1 | 1222998-36-8 | sc-396760 | 10 mg | $240.00 | 7 | |
Torin 1 is a potent inhibitor of both mTORC1 and mTORC2, similar to PP242. It can inhibit 1700013G24Rik by disrupting the mTOR signaling pathway, which is involved in the regulation of various cellular processes including those associated with 1700013G24Rik. | ||||||