1700013G24Rik Activators
Rictor Activators encompass a suite of compounds that indirectly augment the functional activity of Rictor through various signaling pathways, primarily the PI3K/AKT/mTOR axis. For instance, Insulin and IGF-1 both act through this axis to promote the production of PIP3, which facilitates AKT's interaction with mTORC2, thereby enhancing Rictor's role in AKT phosphorylation and subsequent cellular survival mechanisms. Similarly, compounds such as A-443654, although they directly activate AKT, could increase the functional demand on mTORC2 and thus Rictor's activity.
Epothilone B and Palmitic Acid, through their respective influence on microtubule stabilization and mTORC1, could also modulate mTORC2 function, suggesting an indirect route to Rictor activation. Additionally, the interaction of the protein with other cellular molecules can be explored through immunoprecipitation followed by mass spectrometry, which can identify binding partners and suggest involvement in specific cellular pathways. Gene knockout studies, facilitated by CRISPR-Cas9 technology, enable researchers to observe the effects of a complete loss of the gene's function, providing substantial clues about its role in the organism. Through the integration of gene expression data, protein interaction networks, and structural analyses, researchers can construct a detailed biological profile of the gene, enhancing our understanding of its contribution to the complex network of genetic regulation within the cell.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
AICAR activates AMPK which, when phosphorylated, can lead to the activation of the mTORC2 complex involving Rictor. This activation enhances the kinase activity of mTORC2, indirectly promoting the phosphorylation and activation of downstream targets. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Insulin binds to its receptor and activates the PI3K signaling pathway, resulting in the production of PIP3 and subsequent activation of AKT. Rictor, as part of mTORC2, is necessary for the full activation of AKT by phosphorylating it at Ser473. | ||||||
Spermine | 71-44-3 | sc-212953A sc-212953 sc-212953B sc-212953C | 1 g 5 g 25 g 100 g | $61.00 $196.00 $277.00 $901.00 | 1 | |
Spermine has been shown to activate AMPK. The activation of AMPK can lead to downstream activation of mTORC2, where Rictor is a critical component, thereby potentially enhancing AKT phosphorylation and subsequent cell survival pathways. | ||||||
AICA-Riboside, 5′-Phosphate | 3031-94-5 | sc-202448B sc-202448C sc-202448 sc-202448A | 5 mg 10 mg 50 mg 100 mg | $184.00 $281.00 $505.00 $938.00 | 1 | |
ZMP is an AMP analog that activates AMPK. Once activated, AMPK can enhance the activity of mTORC2, which includes Rictor, affecting cytoskeletal rearrangements and promoting cell survival and migration. | ||||||
Oleic Acid | 112-80-1 | sc-200797C sc-200797 sc-200797A sc-200797B | 1 g 10 g 100 g 250 g | $37.00 $104.00 $580.00 $1196.00 | 10 | |
Oleic Acid can activate PPARs, which are transcription factors that regulate gene expression linked to the mTOR pathway. This regulation could lead to the activation of mTORC2, thereby enhancing the activity of Rictor. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol activates SIRT1 which can modulate mTORC2 activity. SIRT1 activation leads to deacetylation of mTORC2 components, potentially increasing the activity of Rictor and its role in AKT phosphorylation and cell survival. | ||||||
L-Lysine | 56-87-1 | sc-207804 sc-207804A sc-207804B | 25 g 100 g 1 kg | $95.00 $263.00 $529.00 | ||
L-Lysine is an essential amino acid that can modulate the mTOR pathway. It is known to enhance mTORC2 signaling, indirectly increasing the functional activity of Rictor and its role in the phosphorylation of AKT at Ser473. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $79.00 | 2 | |
Metformin activates AMPK, leading to mTORC2 activation. Rictor is a critical part of mTORC2, and its activity is enhanced by metformin-induced AMPK activation, contributing to the regulation of cell growth and proliferation. | ||||||