17β-HSD11 Activators

Common 17β-HSD11 Activators include, but are not limited to Fenofibrate CAS 49562-28-9, Clofibrate CAS 637-07-0, Gemfibrozil CAS 25812-30-0, Bezafibrate CAS 41859-67-0 and WY 14643 CAS 50892-23-4.

17β-HSD11, also known as HSD17B11 (Hydroxysteroid 17-beta dehydrogenase 11), is an intriguing member of the 17β-hydroxysteroid dehydrogenases (17β-HSDs) family. This family is renowned for its essential roles in the meticulous balance of activation and inactivation processes of steroid hormones. While 17β-HSD11 itself is efficiently regulated by peroxisome proliferator-activated receptor-α (PPARα) predominantly in the intestine and the liver, other members of this family showcase an array of biological functions. For instance, HSD17B1 stands out as a pivotal enzyme in the estrogen metabolic pathway, being responsible for the activation of estrogens from their weaker precursors by catalyzing the biosynthesis' final step. This transformative process is indispensable for maintaining proper estrogenic levels vital for various physiological operations.

Diving deeper into the family, HSD17B12 is another significant member that wears multiple hats in cellular pathways. Not only does it play a role in the prostaglandin synthesis pathway, influencing ovarian function and fertility regulation, but it also carves a niche in the fatty acid biosynthesis pathway. Its involvement in the latter has been linked to predicting outcomes in colorectal cancer, underscoring the importance of this enzyme in disease contexts. As we shift our focus back to 17β-HSD11, the burgeoning interest in this protein suggests that 17β-HSD11 Activators would be compounds tailored to heighten the activity or expression of 17β-HSD11. These activators might either foster a direct interaction with the protein or modulate the intertwined signaling pathways it's associated with, amplifying the innate roles of 17β-HSD11.