14-3-3 ζ Activators
The chemical class of 14-3-3 ζ activators comprises a diverse array of compounds that modulate the activity of the 14-3-3 ζ isoform. Fusicoccin, R18, BV02, Deracoxib, SFN (Sulforaphane), LY294002, AZD5363, GW4064, MRT68921, PI-103, NSC 23766, and Ibrutinib have been identified as activators, each with unique mechanisms of action. These activators directly or indirectly influence 14-3-3 ζ by binding to specific domains, inducing conformational changes, or modulating signaling pathways associated with 14-3-3 ζ-mediated cellular processes. Fusicoccin, R18, and BV02 directly activate 14-3-3 ζ through specific binding, highlighting their utility as tools for studying the regulatory mechanisms governed by this protein.
Deracoxib, SFN, LY294002, AZD5363, GW4064, MRT68921, PI-103, NSC 23766, and Ibrutinib indirectly activate 14-3-3 ζ by modulating various signaling pathways, such as Akt/mTOR, Nrf2, PI3K, FXR, CK2/PI3K, PI3K/mTOR, Rac1, and BTK. This diverse array of activators provides valuable insights into the intricate network of interactions connecting different signaling cascades to 14-3-3 ζ-mediated cellular functions. Understanding the specific biochemical and cellular pathways influenced by these activators is essential for unraveling the complex regulatory mechanisms orchestrated by 14-3-3 ζ and its role in maintaining cellular homeostasis. The identified activators within this class serve as valuable tools for probing the functional implications of 14-3-3 ζ in various physiological and pathological contexts.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
SFN (Sulforaphane), found in cruciferous vegetables, indirectly activates 14-3-3 ζ by modulating the Nrf2 pathway. SFN enhances Nrf2 nuclear translocation and transcriptional activity, influencing 14-3-3 ζ-mediated cellular processes. The compound's impact on 14-3-3 ζ provides insights into the interplay between oxidative stress response and 14-3-3 ζ-regulated pathways. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that indirectly influences 14-3-3 ζ activity by targeting the PI3K/Akt pathway. Inhibition of PI3K impacts downstream signaling cascades, altering 14-3-3 ζ interactions with target proteins. LY294002's impact on 14-3-3 ζ provides valuable insights into the regulatory mechanisms connecting PI3K/Akt signaling to 14-3-3 ζ-mediated cellular functions. | ||||||
AZD5363 | 1143532-39-1 | sc-503190 | 5 mg | $309.00 | ||
AZD5363, an Akt kinase inhibitor, indirectly influences 14-3-3 ζ activity by targeting the Akt/mTOR pathway. Inhibition of Akt by AZD5363 alters downstream signaling events, modulating 14-3-3 ζ interactions with target proteins. The compound's impact on 14-3-3 ζ provides insights into the crosstalk between Akt signaling and 14-3-3 ζ-mediated cellular processes. | ||||||
GW 4064 | 278779-30-9 | sc-218577 | 5 mg | $93.00 | 13 | |
GW4064, an FXR agonist, indirectly activates 14-3-3 ζ by modulating the FXR signaling pathway. Activation of FXR influences downstream signaling events, altering 14-3-3 ζ interactions with target proteins. GW4064's impact on 14-3-3 ζ provides insights into the regulatory mechanisms connecting FXR signaling to 14-3-3 ζ-mediated cellular functions. | ||||||
MRT 68921 | 1190379-70-4 | sc-507429 | 10 mg | $276.00 | ||
MRT68921 is a dual CK2/PI3K inhibitor that indirectly influences 14-3-3 ζ activity by targeting the CK2 and PI3K signaling pathways. Inhibition of CK2 and PI3K impacts downstream signaling cascades, altering 14-3-3 ζ interactions with target proteins. MRT68921's impact on 14-3-3 ζ provides valuable insights into the regulatory mechanisms connecting CK2 and PI3K signaling to 14-3-3 ζ-mediated cellular functions. | ||||||
PI-103 | 371935-74-9 | sc-203193 sc-203193A | 1 mg 5 mg | $32.00 $128.00 | 3 | |
PI-103 is a dual PI3K/mTOR inhibitor that indirectly influences 14-3-3 ζ activity by targeting the PI3K/mTOR signaling pathway. Inhibition of PI3K/mTOR alters downstream signaling events, modulating 14-3-3 ζ interactions with target proteins. PI-103's impact on 14-3-3 ζ provides insights into the regulatory mechanisms connecting PI3K/mTOR signaling to 14-3-3 ζ-mediated cellular functions. | ||||||
Ibrutinib | 936563-96-1 | sc-483194 | 10 mg | $153.00 | 5 | |
Ibrutinib, a Bruton's tyrosine kinase (BTK) inhibitor, indirectly influences 14-3-3 ζ activity by modulating the BTK signaling pathway. Inhibition of BTK impacts downstream signaling events, altering 14-3-3 ζ interactions with target proteins. Ibrutinib's impact on 14-3-3 ζ provides insights into the regulatory mechanisms connecting BTK signaling to 14-3-3 ζ-mediated cellular functions. | ||||||