14-3-3 ζ Inhibitors
The class of 14-3-3 ζ inhibitors encompasses a diverse array of chemical entities that modulate cellular processes through the indirect or direct inhibition of 14-3-3 ζ. These small molecules play a crucial role in dissecting the intricate regulatory networks associated with 14-3-3 ζ, a multifunctional protein involved in various signaling pathways. The presented inhibitors, such as R18 and TCS-OX2-029, exert their effects by influencing the PI3K/Akt/mTOR pathway, leading to altered interactions between Akt and 14-3-3 ζ. Others, like BV02 and its derivatives, target the Ras/Raf/MEK/ERK pathway, indirectly inhibiting 14-3-3 ζ through modulation of Ras activity.
Fusicoccin, a natural product in this class, interacts with the plasma membrane H+-ATPase, indirectly impacting 14-3-3 ζ and its binding partners. Additionally, compounds like FTY720 and 5-Iodotubercidin modulate S1P receptors and interfere with the PI3K/Akt/mTOR pathway, respectively, contributing to the indirect inhibition of 14-3-3 ζ. CEP-1347 influences the JNK signaling pathway, and sc-66 modulates the Akt/mTOR pathway, both indirectly affecting 14-3-3 ζ function. The class also includes Indirubin, a natural product that alters the Wnt/β-catenin pathway, indirectly inhibiting 14-3-3 ζ. BV02 Derivative II, another compound in this category, influences the Ras/Raf/MEK/ERK pathway, contributing to its indirect inhibitory effects on 14-3-3 ζ.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Fusicoccin | 20108-30-9 | sc-200754 sc-200754A sc-200754B | 1 mg 5 mg 10 mg | $408.00 $2040.00 $4080.00 | 7 | |
Fusicoccin is a natural product that indirectly influences 14-3-3 ζ by interacting with the plasma membrane H+-ATPase. This interaction leads to activation of the H+-ATPase, affecting downstream signaling pathways and altering the interaction of 14-3-3 ζ with its binding partners. The indirect inhibition of 14-3-3 ζ contributes to the pharmacological effects of Fusicoccin. | ||||||
Tie2 Kinase Inhibitor Inhibitor | 948557-43-5 | sc-356156 | 5 mg | $360.00 | ||
TCS-OX2-029 is a small molecule inhibitor that indirectly affects 14-3-3 ζ by modulating the PI3K/Akt/mTOR pathway. Its inhibition of PI3K leads to decreased Akt phosphorylation, influencing the Akt/14-3-3 ζ interaction. This indirect inhibition impacts cellular processes governed by 14-3-3 ζ, contributing to the pharmacological effects of TCS-OX2-029. | ||||||
FTY720 | 162359-56-0 | sc-202161 sc-202161A sc-202161B | 1 mg 5 mg 25 mg | $32.00 $75.00 $118.00 | 14 | |
FTY720, also known as Fingolimod, is a sphingosine analogue that indirectly inhibits 14-3-3 ζ by modulating the S1P receptor. Its interaction with the receptor alters downstream signaling pathways, influencing the interaction of 14-3-3 ζ with its binding partners. The indirect inhibition of 14-3-3 ζ contributes to the pharmacological effects of FTY720. | ||||||
5-Iodotubercidin | 24386-93-4 | sc-3531 sc-3531A | 1 mg 5 mg | $150.00 $455.00 | 20 | |
5-Iodotubercidin is a chemical compound that indirectly inhibits 14-3-3 ζ by interfering with the PI3K/Akt/mTOR pathway. Its effects on PI3K lead to decreased Akt phosphorylation, influencing the Akt/14-3-3 ζ interaction. This indirect inhibition impacts cellular processes governed by 14-3-3 ζ, contributing to the pharmacological effects of 5-Iodotubercidin. | ||||||
Indirubin | 479-41-4 | sc-201531 sc-201531A | 5 mg 25 mg | $112.00 $515.00 | 4 | |
Indirubin is a natural product that indirectly influences 14-3-3 ζ by modulating the Wnt/β-catenin pathway. Its effects on Wnt signaling alter downstream events, influencing the interaction of 14-3-3 ζ with its binding partners. The indirect inhibition of 14-3-3 ζ contributes to the pharmacological effects of Indirubin. | ||||||